Document Detail

The effects of cholecystokinin on stimulation-induced feeding and self-stimulation.
MedLine Citation:
PMID:  10628738     Owner:  NLM     Status:  MEDLINE    
Cholecystokinin (CCK) is a peptide hormone which controls a number of important functions during the process of digestion. It is present in the gut and the central nervous system, although its exact role in the latter is not yet clear. Our interest was in the effects of intraperitoneal and intracerebral injections of CCK on brain stimulation reward and stimulation-induced feeding. Period thresholds for rewarding stimulation were unaffected by either route of peptide administration, whereas stimulation-induced feeding thresholds were weakly increased by centrally injected CCK. In addition, we evaluated stimulation-induced feeding using a more resolved measure and found it to provide clearer results. By actually measuring the amount of food eaten during a stimulation-induced feeding session, and not only the occurrence of feeding, CCK was shown to systematically decrease the total intake as a function of dose in an inverse manner. The efficiency of food utilization was calculated for each animal during the different phases of the experiment in order to monitor the effects of CCK on the animals' overall health. Centrally administered CCK appeared to increase the animals' efficiency and, furthermore, this level was sustained for the entire post-injection phase, about 2 weeks, suggesting a relatively enduring increase in metabolic rate. While the functional role of central CCK and other gastric peptides requires clarification, analyses which exploit the stimulation-induced feeding paradigm need to make use of more clearly defined microstructural variables.
A T Konkle; S L Kubelka; C Bielajew
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Behavioural brain research     Volume:  107     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-01-31     Completed Date:  2000-01-31     Revised Date:  2006-03-01    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  145-52     Citation Subset:  IM    
School of Psychology, University of Ottawa, Ont., Canada.
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MeSH Terms
Brain Mapping
Cholecystokinin / physiology*
Energy Metabolism / physiology
Feeding Behavior / physiology*
Hypothalamic Area, Lateral / physiology
Nerve Net / physiology
Rats, Sprague-Dawley
Self Stimulation / physiology*
Reg. No./Substance:

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