| The effects of pentylenetetrazol, chlordiazepoxide and caffeine in rats tested in the elevated plus-maze depend on the experimental illumination. | |
| | |
MedLine Citation:
|
PMID: 20933019 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The so-called anxiolytic and anxiogenic drugs are considered to cause, respectively, increases and decreases in plus-maze open arm exploration, without modifying locomotor activity occurring in the closed arms in an elevated plus-maze when the animals are tested in an illuminated environment. Simply testing animals in the dark also increases open arm exploration, which may be interpreted as an anxiolytic effect. We investigated the effects of two GABAergic drugs, pentylenetetrazol (10 and 20 mg/kg) and chlordiazepoxide (1.5 and 3 mg/kg), and one non-GABAergic drug, caffeine (10 and 30 mg/kg) on anxiety levels of rats tested in the elevated plus-maze under two illumination conditions, light or dark. All animals explored more the open arms in the dark. In the light, pentylenetetrazol decreased open arm exploration while chlordiazepoxide had the opposite effect. Neither pentylenetetrazol nor chlordiazepoxide had any effect in the dark. Caffeine, increased open arms exploration in both illumination conditions. These results indicate that light triggers aversion, a response mediated by GABA since the GABAergic drugs, but not caffeine, were ineffective when the rats were tested in the dark. |
| | |
Authors:
|
Andrea Milena Becerra Garcia; Fernando P Cardenas; Silvio Morato |
Related Documents
:
|
20567809 - Posture of the arm when grasping spheres to place them elsewhere. 19710379 - Long-latency responses during reaching account for the mechanical interaction between t... 528089 - Biomechanical study of the pitching elbow. 19996329 - Current concepts: scapular dyskinesis. 18036839 - Shoulder kinematics in patients with full-thickness rotator cuff tears after a subacrom... 17981379 - Scapulohumeral rhythm and associated spinal motion. 22587379 - Atypical signatures of motor variability found in an individual with asd. 22279169 - Keeping returns optimal: gain control exerted through sensitivity adjustments in the ha... 10505189 - The missing-fundamental illusion at isoluminance. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-07 |
Journal Detail:
|
Title: Behavioural brain research Volume: 217 ISSN: 1872-7549 ISO Abbreviation: Behav. Brain Res. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2010-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 171-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
|
Facultad de Psicología, Universidad de La Sabana, Chía, Colombia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: New in vitro method for evaluating antiviral activity of acyclic nucleoside phosphonates against pla...
Next Document: Neurobiology of decision-making in adolescents.