Document Detail


The effects of chemical versus locomotory stimuli on respiratory muscle activity in the awake dog.
MedLine Citation:
PMID:  2609026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using 6 chronically instrumented awake dogs, we contrasted the ventilatory and respiratory muscle EMG responses to steady-state normoxic hypercapnia with those occurring at similar levels of ventilation during steady-state treadmill exercise. During hypercapnia, increases in ventilatory output were primarily due to increments in VT whereas during exercise, increases in minute ventilation were due primarily to increases in frequency. With either hyperpnea, augmentation of both inspiratory and expiratory muscle EMG activity occurred but only diaphragmatic EMG activity was strongly correlated with tidal volume changes in both conditions. Using both EMGs and thoraco-abdominal pressures, we found that with increasing chemical or locomotory stimuli, during inspiration (1) diaphragmatic EMG activation occurred sooner relative to the onset of mechanical flow and (2) that respiratory muscles other than the diaphragm contributed significantly to the generation of inspiratory flow and VT either actively or passively through recoil. Post-inspiratory inspiratory activity of the crural diaphragm shortened relative to control in hypercapnia but did not change in exercise. Finally, during mild hyperpneas, end-expiratory lung volume did not change significantly in either hypercapnia or exercise but decreased at the higher levels of hyperpnea only during exercise. This may reflect differences not in the magnitude of phasic expiratory muscle activity, but rather in the degree of tonic abdominal muscle activation between the two conditions.
Authors:
D M Ainsworth; C A Smith; S W Eicker; K S Henderson; J A Dempsey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  78     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-02-13     Completed Date:  1990-02-13     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  163-76     Citation Subset:  IM; S    
Affiliation:
John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin School of Medicine, Madison 53705.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Electromyography
Female
Hypercapnia / physiopathology*
Locomotion / physiology*
Lung Volume Measurements
Physical Exertion / physiology*
Respiratory Muscles / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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