| The effects of changing atmospheric oxygen concentrations and background radiation levels on radiogenic DNA damage rates. | |
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MedLine Citation:
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PMID: 11669208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Both background radiation levels and atmospheric oxygen concentrations have changed dramatically over the history of life on earth. Because oxygen has a strong modifying influence on radiogenic mutation rates, these factors must be considered jointly to determine changes in radiogenic mutation rates over time. Using accepted models that describe how both of these parameters have changed through time, we find that radiogenic mutation rates in organisms have fluctuated between about 1.5 to 2.5 times current levels through most of the history of life. The results of this study have interesting implications that may impact our understanding of how modern organisms respond to radiation damage and of models that use molecular clocks to date species divergence times. It is also possible that changing oxygen levels have served to buffer mutation rate changes that result from changes in background radiation levels over time. |
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Authors:
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P A Karam; S A Leslie; A Anbar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Health physics Volume: 81 ISSN: 0017-9078 ISO Abbreviation: Health Phys Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-10-23 Completed Date: 2001-11-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985093R Medline TA: Health Phys Country: United States |
Other Details:
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Languages: eng Pagination: 545-53 Citation Subset: IM |
Affiliation:
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University of Rochester, Department of Environmental Medicine, Rochester, NY 14642, USA. Andrew_Karam@urmc.rochester.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Background Radiation* DNA / radiation effects* DNA Damage* DNA Repair Evolution Models, Theoretical Mutation Oxygen / pharmacology* |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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