Document Detail


The effects of central injections of adenosine analogs on blood pressure and heart rate in the rat.
MedLine Citation:
PMID:  3748319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rats were implanted with chronic indwelling cannulae into the lateral cerebral ventricle. After recovery from surgery, acute experiments on blood pressure were conducted under methoxyflurane/nitrous oxide anesthesia. Rats were injected intracerebroventricularly with two adenosine analogs, 5'-N-ethylcarboxaminidoadenosine (NECA) and (-)-N-(1-methyl-2-phenylethyl)adenosine(L-phenylisopropyladenosine) (L-PIA), and the effects on blood pressure and heart rate recorded. Both analogs produced dose-related reductions in blood pressure and heart rate with L-PIA producing a more potent depression of heart rate than NECA. These effects on blood pressure and heart rate were antagonized by parenteral injections of caffeine. In separate experiments, the responses of blood pressure and heart rate to microinjection of NECA into the brainstem of rats anaesthetized with methoxyflurane/nitrous oxide were also examined. Microinjection of 2.7 nmol/kg into the fourth ventricle in the region of the area postrema produced a profound and long-lasting depression of blood pressure and heart rate. These results show that central injections of analogs of adenosine can influence the areas of the central nervous system involved in the control of cardiovascular function.
Authors:
R A Barraco; J W Phillis; W R Campbell; D R Marcantonio; R S Salah
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuropharmacology     Volume:  25     ISSN:  0028-3908     ISO Abbreviation:  Neuropharmacology     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-10-21     Completed Date:  1986-10-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  675-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
2-Chloroadenosine
Adenosine / analogs & derivatives*,  pharmacology
Adenosine-5'-(N-ethylcarboxamide)
Animals
Blood Pressure / drug effects*
Diastole
Heart Rate / drug effects*
Injections, Intraventricular
Male
Phenylisopropyladenosine / pharmacology*
Rats
Rats, Inbred Strains
Systole
Grant Support
ID/Acronym/Agency:
RR-08167-OX/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
146-77-0/2-Chloroadenosine; 29193-86-0/Phenylisopropyladenosine; 35920-39-9/Adenosine-5'-(N-ethylcarboxamide); 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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