Document Detail


The effects of cell density and metabolite flux on cellular dynamics.
MedLine Citation:
PMID:  366054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Density-dependent regulation of cell growth in tissue culture is a well-known phenomenon but the mechanism of regulation remains obscure. Here we explore the effects of cell density and metabolite flux on the collective dynamics of a cell population. The intracellular dynamics are modelled by positive feedback kinetic mechanisms of the kind known to apply to yeast cells. Several experimental observations related to glycolytic oscillations are predicted and it is suggested that the general conclusions may be applicable in a broader context.
Authors:
H G Othmer; J A Aldridge
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of mathematical biology     Volume:  5     ISSN:  0303-6812     ISO Abbreviation:  J Math Biol     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1979-03-13     Completed Date:  1979-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7502105     Medline TA:  J Math Biol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  169-200     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cells / metabolism*
Feedback
Glycolysis*
Kinetics
Mathematics
Models, Biological
Saccharomyces cerevisiae / metabolism

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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