Document Detail

The effects of catecholamines on pumping activity in isolated bovine mesenteric lymphatics.
MedLine Citation:
PMID:  6875969     Owner:  NLM     Status:  MEDLINE    
Bovine mesenteric lymphatics of 8 cm length were cannulated and arranged so that pressure changes produced by spontaneous contractions and accompanying flow could be measured. The mean frequency of spontaneous contractions, although constant for any one vessel, varied between vessels from 0.5 to 5.2 beats/min (mean 2.6, S.D. 1.6, n = 33). Noradrenaline (100 ng/ml.) invariably increased frequency of contractions but flow was increased only in those vessels which had a low resting frequency. In those vessels which had a higher resting frequency, flow was decreased despite the increase in frequency because stroke volume decreased. This may have been due to increased pace-maker activity causing desynchronization of the contractile activity in the vessel wall and thus decreased effectiveness of pumping. High doses (greater than 1 microgram/ml.) of noradrenaline invariably depressed flow. Isoprenaline slowed the frequency of spontaneous contractions and this either had little effect on flow (due to an increased filling time and thus stroke volume) or depressed it, finally abolishing it entirely at higher doses. It is concluded that in suitable dosage (which varies for different vessels) noradrenaline is capable of enhancing flow and this might, at least in part, explain the increase in lymph flow resulting from noradrenaline infusion in living animals.
N G McHale; I C Roddie
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of physiology     Volume:  338     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  527-36     Citation Subset:  IM    
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MeSH Terms
Isoproterenol / pharmacology*
Lymph / physiology
Lymphatic System / drug effects*
Mesentery / physiology
Muscle Contraction / drug effects
Muscle, Smooth / drug effects,  physiology
Norepinephrine / pharmacology*
Time Factors
Reg. No./Substance:
51-41-2/Norepinephrine; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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