Document Detail

The effects of carvedilol a nonselective beta-blocker on portal hemodynamics in cirrhosis.
MedLine Citation:
PMID:  15526508     Owner:  NLM     Status:  MEDLINE    
AIM: To assess the effects of Carvedilol, a 3rd-generation nonselective beta blocker with alpha1-adrenergic activity on portal and systemic homodynamic in patients with cirrhosis and portal hypertension.
METHODS: Fifty patients with cirrhosis and portal hypertension were divided into two groups and statistically compared as follows: group I - 25 patients received Carvedilol, 12.5 mg/day and group II - 25 patients received placebo for six days. All the patients had hemodynamic, endocrine and renal measurements before and after administration of Carvedilol or placebo. They underwent creatinine clearance, lithium clearance, plasma renin activity, concentration of plasma aldosteron and urinary sodium excretion. Hemodynamic effects were assessed by portal flow volume and velocity, cardiac output and medium blood pressure.
RESULTS: Carvedilol significantly increased the portal blood flow and velocity (p<0.05). Carvedilol reduced the medium blood pressure (p<0.001) with statistically insignificant alterations in creatinine clearance and 24-hours urinary sodium excretion. Carvedilol also reduced the concentration of plasma aldosteron (p < 0.002).
CONCLUSIONS: Carvedilol can be used as an alternative drug for the prophylactic treatment of portal hypertension with careful monitoring of blood pressure regarding its hypotensive effects.
Carmen Fierbinteanu-Braticevici; Maria Udeanu; P Dragomir; D Andronescu
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Romanian journal of internal medicine = Revue roumaine de médecine interne     Volume:  41     ISSN:  1220-4749     ISO Abbreviation:  Rom J Intern Med     Publication Date:  2003  
Date Detail:
Created Date:  2004-11-05     Completed Date:  2004-12-09     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9304507     Medline TA:  Rom J Intern Med     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  247-54     Citation Subset:  IM    
Medical Clinic II, Department of Gastroenterology, University Hospital, Bucharest, Romania.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology,  therapeutic use*
Carbazoles / pharmacology,  therapeutic use*
Hemodynamics / drug effects
Hypertension, Portal / drug therapy*,  etiology,  physiopathology
Liver Circulation / drug effects
Liver Cirrhosis / complications,  physiopathology
Middle Aged
Propanolamines / pharmacology,  therapeutic use*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0K47UL67F2/carvedilol

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