Document Detail

The effects of cardiac denervation on renal function.
MedLine Citation:
PMID:  1153419     Owner:  NLM     Status:  MEDLINE    
Assessment of certain parameters of renal function were carried out before and 1 wk after total denervation of the heart by a method which leaves nerves to other organs intact. No changes in mean blood pressure, central venous pressure, cardiac output, GFR, or RPF were noted after cardiac denervation. UNaV after a low sodium diet was similar during a control period before and after denervation, but in response to expansion of the plasma volume a 3-fold greater natriuresis was seen in the denervated group. Alterations in the filtered load of sodium, the secretion of aldosterone, or most of the recently described physical and compositional factors known to influence sodium excretion cannot adequately explain this natriuresis. Expansion of an already augmented plasma volume after denervation or the possibility of a natriuretic or antinatriuretic factor with afferents interrupted in the process of cardiac denervation must be considered as etiologic factors.
J J Mulcahy; W P Geis; R L Malvin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  149     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-10-21     Completed Date:  1975-10-21     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  422-6     Citation Subset:  IM    
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MeSH Terms
Aminohippuric Acids / urine
Blood Pressure
Cardiac Output
Creatinine / urine
Glomerular Filtration Rate
Heart / innervation*,  physiology*
Kidney / physiology*
Kidney Function Tests
Plasma Volume
Potassium / blood,  urine
Regional Blood Flow
Sodium / blood,  urine
Venous Pressure
Reg. No./Substance:
0/Aminohippuric Acids; 60-27-5/Creatinine; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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