Document Detail

The effects of carbon monoxide on respiratory chemoreflexes in humans.
MedLine Citation:
PMID:  15016588     Owner:  NLM     Status:  MEDLINE    
As protection against low-oxygen and high-carbon-dioxide environments, the respiratory chemoreceptors reflexly increase breathing. Since CO is also frequently present in such environments, it is important to know whether CO affects the respiratory chemoreflexes responsiveness. Although the peripheral chemoreceptors fail to detect hypoxia produced by CO poisoning, whether CO affects the respiratory chemoreflex responsiveness to carbon dioxide is unknown. The responsiveness of 10 healthy male volunteers were assessed before and after inhalation of approximately 1200 ppm CO in air using two iso-oxic rebreathing tests; hypoxic, to emphasize the peripheral chemoreflex, and hyperoxic, to emphasize the central chemoreflex. Although mean (SEM) COHb values of 10.2 (0.2)% were achieved, no statistically significant effects of CO were observed. The average differences between pre- and post-CO values for ventilation response threshold and sensitivity were -0.5 (0.9) mmHg and 0.8 (0.3) L/min/mmHg, respectively, for hyperoxia, and 0.7 (1.1) mmHg and 1.2 (0.8) L/min/mmHg, respectively, for hypoxia. The 95% confidence intervals for the effect of CO were small. We conclude that environments with low levels of CO do not have a clinically significant effect acutely on either the central or the peripheral chemoreflex responsiveness to carbon dioxide.
Alex E Vesely; Ron B Somogyi; Hiroshi Sasano; Nobuko Sasano; Joseph A Fisher; James Duffin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental research     Volume:  94     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-12     Completed Date:  2004-05-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  227-33     Citation Subset:  IM    
Department of Physiology, 1 King's College Circle, University of Toronto, Toronto, Ont., Canada M5S 1A8.
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MeSH Terms
Air Pollutants / toxicity*
Analysis of Variance
Carbon Dioxide / physiology*
Carbon Monoxide / toxicity*
Chemoreceptor Cells / drug effects*,  physiology
Middle Aged
Pulmonary Gas Exchange / drug effects
Pulmonary Ventilation / drug effects
Reflex / drug effects*,  physiology
Respiratory Mechanics / drug effects*,  physiology
Reg. No./Substance:
0/Air Pollutants; 124-38-9/Carbon Dioxide; 630-08-0/Carbon Monoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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