| The effects of captopril on blood pressure in essential hypertensive patients with low or normal plasma renin activity. Interference with autonomic nervous system. | |
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MedLine Citation:
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PMID: 7018859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Captopril was administered to 12 essential hypertensive patients with low or normal plasma renin activity in order to evaluate its effectiveness in decreasing blood pressure and to determine whether the inhibition of converting enzyme could interfere with sympathetic neural activity. Captopril, at the doses of 150-450 mg/die, normalized blood pressure in 5 patients (responders) and had no effect on 7 patients (non responders). A significant decrease in heart rate was observed in all patients. Captopril failed to significantly increase plasma renin activity in all patients. Supine plasma levels of catecholamines were significantly higher in responders compared with non responders and decreased significantly after treatment with captopril. The physiological study we performed on all patients suggests an overall integrity of the baroreceptor reflex arc and vascular reactivity to stress before as well as after treatment with captopril. On the contrary, the bradycardia induced by diving test was significantly greater after treatment than before therapy. These findings suggest that the antihypertensive effect of converting enzyme inhibition may be partly due to interference with sympathetic neural activity. Moreover captopril seems to exert an important effect on parasympathetic activity irrespective of blood pressure changes. |
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Authors:
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E Degli Esposti; C Chiarini; A Masi; A Santoro; A Sturani; A Umile; A Zuccalà; P Zucchelli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental hypertension Volume: 3 ISSN: 0148-3927 ISO Abbreviation: Clin Exp Hypertens Publication Date: 1981 |
Date Detail:
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Created Date: 1981-09-25 Completed Date: 1981-09-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7803060 Medline TA: Clin Exp Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 439-54 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autonomic Nervous System / physiopathology* Blood Pressure / drug effects* Captopril / therapeutic use* Epinephrine / blood Female Heart Rate / drug effects Humans Hypertension / drug therapy* Male Middle Aged Norepinephrine / blood Proline / analogs & derivatives* Renin / blood* Sympathetic Nervous System / drug effects |
| Chemical | |
Reg. No./Substance:
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147-85-3/Proline; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 62571-86-2/Captopril; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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