| The effects of calcium dobesilate on the mechanical function of rat hearts. | |
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MedLine Citation:
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PMID: 19543197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Calcium dobesilate is an angio-protective agent that has positive effects on hemorheological parameters. It decreases blood and plasma viscosity, thrombocyte aggregation, and microvascular hyperpermeability. It is an antioxidant that increases endothelial-derived vasodilator substance secretion. In this experimental study, the effects of calcium dobesilate on myocardial ischemia reperfusion injury were investigated. METHODS: Using the Langendorff setup, 24 adult Wistar albino rat hearts were perfused. MeanP (mean pressure perfusing the coronary arteries), PSP (maximum left ventricle pressure), +dp/dt(max) (change in contraction power over time), -dp/dt(max) (change in relaxing power over time), PP (peak systolic pressure-minimum balloon pressure) and bpm (number of heart beats per minute) were evaluated. The control group (N.=6) was perfused with Tyrode solution alone. The other three groups (N.=6 for each group) were perfused with the Tyrode solution and calcium dobesilate either before ischemia, during the ischemia reperfusion period, or during the reperfusion-only period. RESULTS: The meanP values were significantly higher in groups perfused by calcium dobesilate. For other parameters, calcium dobesilate did not demonstrate a positive effect. CONCLUSIONS: This study showed that calcium dobesilate may have cardio-protective effects in isolated, perfused rat hearts. In hearts perfused by calcium dobesilate, the increase in mean P may be explained by the increase in endothelium-derived vasodilator substances. Further studies are needed to better characterize the myocardial protective effects of calcium dobesilate. |
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Authors:
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I Cihan Ozbek; C Arslan; E Cantürk; O Süzer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of cardiovascular surgery Volume: 50 ISSN: 0021-9509 ISO Abbreviation: J Cardiovasc Surg (Torino) Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-22 Completed Date: 2009-10-29 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0066127 Medline TA: J Cardiovasc Surg (Torino) Country: Italy |
Other Details:
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Languages: eng Pagination: 395-401 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Surgery, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium Dobesilate / pharmacology* Cardiotonic Agents / pharmacology* Coronary Circulation / drug effects Coronary Vessels / drug effects*, physiopathology Disease Models, Animal Female Heart Rate / drug effects Male Myocardial Contraction / drug effects* Myocardial Reperfusion Injury / physiopathology, prevention & control* Rats Rats, Wistar Time Factors Vasodilation / drug effects Ventricular Function, Left / drug effects* Ventricular Pressure / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 20123-80-2/Calcium Dobesilate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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