| The effects of bilateral lung transplantation on ventilatory efficiency, oxygen uptake and the right heart: a two-yr follow-up. | |
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MedLine Citation:
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PMID: 20637037 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Habedank D, Ewert R, Hummel M, Dandel M, Habedank F, Knosalla C, Lehmkuhl HB, Anker SD, Hetzer R. The effects of bilateral lung transplantation on ventilatory efficiency, oxygen uptake and the right heart: a two-yr follow-up. Clin Transplant 2011: 25: E38-E45. © 2010 John Wiley & Sons A/S. Abstract: Background: This study was to examine the course of ventilation/perfusion mismatch (VE/VCO(2) -slope) before and during two-yr follow-up after bilateral lung transplantation (BLTx) and to relate exercise parameters with the reverse right ventricular remodeling. Methods: We prospectively examined 20 patients (nine women; age 46.0 ± 13.0 yr) by cardiopulmonary exercise testing (before and at 3, 6, 12, and 24 months after BLTx), and by echocardiography and blood gas analysis. Etiology of pulmonary failure was chronic obstructive pulmonary disease as well (n = 8), pulmonary hypertension (n = 7), idiopathic fibrosis (n = 3), others (n = 2). Results: The VE/VCO(2) -slope before BLTx was 47.5 (interquartile range 24.5) and declined at 3 months -25.9%, 6 months -30.9%, 12 months -33.9%, and 24 months -35.1% (all p ≤ 0.003) and was then not different from normal. The right ventricular end diastolic diameter RVEDd narrowed from 35.0 (22.5) before to 31.0 (9.0) mm at 3 months after LTx. Similarly, right ventricular systolic pressure (RV(sys) ) decreased from 53.6 ± 28.3 to 26.2 ± 5.2 mmHg (all p < 0.01). RVEDd correlated with VE/VCO(2) -slope before (p < 0.0001) but not after BLTx. PeakVO(2) increased from 10.0 ± 2.3 mL/min per kg before BLTx by 86.5% at 24 months (p < 0.01). Conclusions: The functional status (VE/VCO(2) -slope, peakVO(2) ) improves quickly after lung transplantation and is accompanied by reverse remodeling of the right heart. A correlation between exercise parameters and right heart function was found before BLTx only. |
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Authors:
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Dirk Habedank; Ralf Ewert; Manfred Hummel; Michael Dandel; Friedrich Habedank; Christoph Knosalla; Hans B Lehmkuhl; Stefan D Anker; Roland Hetzer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical transplantation Volume: 25 ISSN: 1399-0012 ISO Abbreviation: Clin Transplant Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-02-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710240 Medline TA: Clin Transplant Country: Denmark |
Other Details:
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Languages: eng Pagination: E38-45 Citation Subset: IM |
Copyright Information:
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© 2010 John Wiley & Sons A/S. |
Affiliation:
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Department of Cardiology, Charité- University Medicine Berlin, Campus Virchow Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Germany Department of Mechanical Engineering Design, University of Rostock, Rostock, Germany Centre for Clinical and Basic Research, IRCCS San Raffaele, Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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