| The effects of bicuculline and muscimol on glutamate-induced feeding behavior in broiler cockerels. | |
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MedLine Citation:
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PMID: 19415297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to examine the effects of intracerebroventricular (ICV) injection of bicuculline (GABA(A) receptor antagonist) and muscimol (GABA(A) receptor agonist) on glutamate-induced eating response in 24-h food-deprived (FD24) broiler cockerels. At first, guide cannula was surgically implanted in the right lateral ventricle of chickens. In experiment 1, birds were ICV injected with different doses of glutamate. In experiment 2, birds were administered with effective dose of glutamate after bicuculline. In experiment 3, chickens received muscimol prior to the injection of glutamate, and cumulative food intake was determined at 3-h postinjection. The results of this study showed that glutamate decreases food consumption in FD24 broiler cockerels (P <or= 0.05), and this reduction occurs in a dose-dependent manner. Moreover, the inhibitory effect of glutamate on food intake was significantly increased with bicuculline pretreatment, and this effect was attenuated with muscimol (P <or= 0.05). These results suggest that there is an interaction between glutamatergic and GABAergic systems (through GABA(A) receptor) on food intake in broiler cockerels. |
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Authors:
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Morteza Zendehdel; Ali Baghbanzadeh; Vahab Babapour; Javad Cheraghi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-05 |
Journal Detail:
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Title: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology Volume: 195 ISSN: 1432-1351 ISO Abbreviation: J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-31 Completed Date: 2009-09-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101141792 Medline TA: J Comp Physiol A Neuroethol Sens Neural Behav Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 715-20 Citation Subset: IM |
Affiliation:
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Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, 14155-6453 Tehran, Iran. zendedel@ut.ac.ir |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Bicuculline / pharmacology* Chickens / physiology* Dose-Response Relationship, Drug Eating / drug effects Feeding Behavior / drug effects* Food Deprivation GABA Agonists / pharmacology* GABA Antagonists / pharmacology* Glutamic Acid / pharmacology Injections, Intraventricular / methods Muscimol / pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/GABA Agonists; 0/GABA Antagonists; 2763-96-4/Muscimol; 485-49-4/Bicuculline; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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