Document Detail

The effects of bicuculline and muscimol on glutamate-induced feeding behavior in broiler cockerels.
MedLine Citation:
PMID:  19415297     Owner:  NLM     Status:  MEDLINE    
This study was designed to examine the effects of intracerebroventricular (ICV) injection of bicuculline (GABA(A) receptor antagonist) and muscimol (GABA(A) receptor agonist) on glutamate-induced eating response in 24-h food-deprived (FD24) broiler cockerels. At first, guide cannula was surgically implanted in the right lateral ventricle of chickens. In experiment 1, birds were ICV injected with different doses of glutamate. In experiment 2, birds were administered with effective dose of glutamate after bicuculline. In experiment 3, chickens received muscimol prior to the injection of glutamate, and cumulative food intake was determined at 3-h postinjection. The results of this study showed that glutamate decreases food consumption in FD24 broiler cockerels (P <or= 0.05), and this reduction occurs in a dose-dependent manner. Moreover, the inhibitory effect of glutamate on food intake was significantly increased with bicuculline pretreatment, and this effect was attenuated with muscimol (P <or= 0.05). These results suggest that there is an interaction between glutamatergic and GABAergic systems (through GABA(A) receptor) on food intake in broiler cockerels.
Morteza Zendehdel; Ali Baghbanzadeh; Vahab Babapour; Javad Cheraghi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-05
Journal Detail:
Title:  Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology     Volume:  195     ISSN:  1432-1351     ISO Abbreviation:  J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-31     Completed Date:  2009-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101141792     Medline TA:  J Comp Physiol A Neuroethol Sens Neural Behav Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  715-20     Citation Subset:  IM    
Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, 14155-6453 Tehran, Iran.
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MeSH Terms
Analysis of Variance
Bicuculline / pharmacology*
Chickens / physiology*
Dose-Response Relationship, Drug
Eating / drug effects
Feeding Behavior / drug effects*
Food Deprivation
GABA Agonists / pharmacology*
GABA Antagonists / pharmacology*
Glutamic Acid / pharmacology
Injections, Intraventricular / methods
Muscimol / pharmacology*
Time Factors
Reg. No./Substance:
0/GABA Agonists; 0/GABA Antagonists; 2763-96-4/Muscimol; 485-49-4/Bicuculline; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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