Document Detail

The effects of the atypical antipsychotic amperozide on vacuous jaw movements in rats: a novel dose response profile.
MedLine Citation:
PMID:  9718279     Owner:  NLM     Status:  MEDLINE    
Classic neuroleptic drugs produce a syndrome of vacuous jaw movements in rats, and this syndrome has been offered as an animal model of early onset extrapyramidal side effects. The atypical antipsychotics do not produce elevations in vacuous jaw movements, or do so only at very high doses. The purpose of the present study was to determine the impact of the putative antipsychotic, amperozide, on vacuous jaw movements in rats. Groups of rats received daily injections of haloperidol (0.2, 0.4, or 0.8 mg/kg), clozapine (2.0, 4.0, 8.0 mg/kg), amperozide (2.0, 4.0, 8.0 mg/kg) or vehicle for 4 weeks. Once per week, rats were observed for the presence of vacuous jaw movements. Haloperidol increased vacuous jaw movements with increasing doses. Clozapine only produced elevations in vacuous jaw movements at the highest dose. In contrast, increasing doses of amperozide resulted in decreasing vacuous jaw movements for this portion of the dose-response curve. This is the first report of the effect of amperozide on vacuous jaw movements and results are discussed in terms of a potentially unique behavioral profile with respect to this behavior.
R E Steinpreis; L Moser; F Parret; E Rutell; J Panos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychopharmacology     Volume:  138     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-10-26     Completed Date:  1998-10-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  107-13     Citation Subset:  IM    
Department of Psychology, University of Wisconsin-Milwaukee, 53211, USA.
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MeSH Terms
Analysis of Variance
Antipsychotic Agents / administration & dosage,  adverse effects*
Clozapine / pharmacology
Dose-Response Relationship, Drug
Extrapyramidal Tracts / drug effects
Haloperidol / pharmacology
Jaw / drug effects*
Movement Disorders*
Piperazines / administration & dosage,  adverse effects*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Antipsychotic Agents; 0/Piperazines; 52-86-8/Haloperidol; 5786-21-0/Clozapine; 75558-90-6/amperozide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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