Document Detail

The effects of atrial ganglionated plexi stimulation on ventricular electrophysiology in a normal canine heart.
MedLine Citation:
PMID:  23392954     Owner:  NLM     Status:  Publisher    
AIMS: Atrial ganglionated plexi (GP) have been shown to modulate atrial electrophysiology and play an important role in atrial fibrillation initiation and maintenance. The purpose of this study was to investigate the effects of atrial GP stimulation (GPS) on ventricular refractoriness, restitution properties and electrical alternans. METHODS: In 12 anesthetized dogs, two multiple electrode catheters were sutured at left and right ventricular free walls for recording. Monophasic action potentials were recorded from six epicardial ventricular sites. Ventricular effective refractory period (ERP), action potential duration (APD) restitution properties and APD alternans were measured at baseline and during GPS. RESULTS: Compared with baseline, GPS significantly prolonged ventricular ERP and APD at all sites and decreased their spatial dispersions (P < 0.05 for all). GPS also significantly flattened ventricular restitution curves and decreased the maximal slope of restitution curves at each site (P < 0.05 for all). APD alternans occurred at shorter pacing cycle length at each site during GPS when compared with baseline (P < 0.05 for all). CONCLUSIONS: GPS prolonged ventricular ERP, decreased the slope of restitution curves and delayed APD alternans, indicating that GPS may exert a protective role for ventricular arrhythmias.
Bo He; Zhibing Lu; Wenbo He; Bing Huang; Lilei Yu; Liu Wu; Bo Cui; Xiaorong Hu; Hong Jiang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-8
Journal Detail:
Title:  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing     Volume:  -     ISSN:  1572-8595     ISO Abbreviation:  J Interv Card Electrophysiol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708966     Medline TA:  J Interv Card Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Cardiology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang, Wuhan, 430060, People's Republic of China.
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