Document Detail

The effects of atorvastatin on coronary endothelial function in patients with recent myocardial infarction.
MedLine Citation:
PMID:  16933577     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Endothelial dysfunction is a key early event in atherosclerosis that occurs in acute coronary syndrome. It was reported that atorvastatin improves the endothelial function of skeletal muscle vessels, but the effect on the coronary artery is unknown. HYPOTHESIS: The purpose of this study is to determine the effects of atorvastatin on coronary endothelial function in humans. METHODS: Non-infarct-related coronary arteries of 48 patients with acute myocardial infarction who had undergone successful percutaneous transluminal coronary angioplasty were examined. Three groups were studied: hyperlipidemia with use of atorvastatin (Group 1, n=17), hyperlipidemia without statin use (Group 2, n=18), and normal cholesterol level controls (Group 3, n=13). Statin treatment was started at discharge. Acetylcholine (Ach) was infused into the coronary artery and the diameter was assessed by quantitative angiography at baseline and after 6 months. RESULTS: Acetylcholine given in doses of 1, 3, 10, and 30 mg/min increased the coronary artery diameter change in a dose-dependent manner. In the initial study, patients in the three groups had similar responses to Ach. The mean diameter change after 6 months was significantly improved in Group 1 compared with Groups 2 and 3 (-11 +/- 3% vs. -20 +/- 7% and -21 +/- 6%, respectively; p < 0.01 in each case). Multivariate regression analysis showed that atorvastatin (p < 0.01) was the significant determinant for improvement of endothelial function. CONCLUSIONS: These findings suggest that atorvastatin improves endothelial function of the coronary artery in patients with myocardial infarction.
Shinobu Hosokawa; Yoshikazu Hiasa; Takeshi Tomokane; Riyo Ogura; Hitoshi Miyajima; Yoshikazu Ohara; Tatsuro Ogata; Kenichiro Yuba; Naoki Suzuki; Takefumi Takahashi; Koichi Kishi; Ryuji Ohtani
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical cardiology     Volume:  29     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-28     Completed Date:  2006-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  357-62     Citation Subset:  IM    
Division of Cardiology, Tokushima Red Cross Hospital, Komatsushima-city, Tokushima, Japan.
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MeSH Terms
Acetylcholine / diagnostic use
Analysis of Variance
Angioplasty, Transluminal, Percutaneous Coronary
Coronary Angiography
Coronary Vessels / drug effects*,  pathology
Endothelium, Vascular / drug effects*,  pathology
Heptanoic Acids / administration & dosage,  therapeutic use*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage,  therapeutic use*
Hyperlipidemias / drug therapy*,  radiography
Middle Aged
Myocardial Infarction / pathology,  therapy
Pyrroles / administration & dosage,  therapeutic use*
Regression Analysis
Time Factors
Reg. No./Substance:
0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin; 51-84-3/Acetylcholine

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