| The effects of atorvastatin on coronary endothelial function in patients with recent myocardial infarction. | |
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MedLine Citation:
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PMID: 16933577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Endothelial dysfunction is a key early event in atherosclerosis that occurs in acute coronary syndrome. It was reported that atorvastatin improves the endothelial function of skeletal muscle vessels, but the effect on the coronary artery is unknown. HYPOTHESIS: The purpose of this study is to determine the effects of atorvastatin on coronary endothelial function in humans. METHODS: Non-infarct-related coronary arteries of 48 patients with acute myocardial infarction who had undergone successful percutaneous transluminal coronary angioplasty were examined. Three groups were studied: hyperlipidemia with use of atorvastatin (Group 1, n=17), hyperlipidemia without statin use (Group 2, n=18), and normal cholesterol level controls (Group 3, n=13). Statin treatment was started at discharge. Acetylcholine (Ach) was infused into the coronary artery and the diameter was assessed by quantitative angiography at baseline and after 6 months. RESULTS: Acetylcholine given in doses of 1, 3, 10, and 30 mg/min increased the coronary artery diameter change in a dose-dependent manner. In the initial study, patients in the three groups had similar responses to Ach. The mean diameter change after 6 months was significantly improved in Group 1 compared with Groups 2 and 3 (-11 +/- 3% vs. -20 +/- 7% and -21 +/- 6%, respectively; p < 0.01 in each case). Multivariate regression analysis showed that atorvastatin (p < 0.01) was the significant determinant for improvement of endothelial function. CONCLUSIONS: These findings suggest that atorvastatin improves endothelial function of the coronary artery in patients with myocardial infarction. |
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Authors:
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Shinobu Hosokawa; Yoshikazu Hiasa; Takeshi Tomokane; Riyo Ogura; Hitoshi Miyajima; Yoshikazu Ohara; Tatsuro Ogata; Kenichiro Yuba; Naoki Suzuki; Takefumi Takahashi; Koichi Kishi; Ryuji Ohtani |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Clinical cardiology Volume: 29 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-28 Completed Date: 2006-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 357-62 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Tokushima Red Cross Hospital, Komatsushima-city, Tokushima, Japan. hoso@tokushima-med.jrc.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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diagnostic use Analysis of Variance Angioplasty, Transluminal, Percutaneous Coronary Coronary Angiography Coronary Vessels / drug effects*, pathology Endothelium, Vascular / drug effects*, pathology Female Heptanoic Acids / administration & dosage, therapeutic use* Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage, therapeutic use* Hyperlipidemias / drug therapy*, radiography Male Middle Aged Myocardial Infarction / pathology, therapy Pyrroles / administration & dosage, therapeutic use* Regression Analysis Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin; 51-84-3/Acetylcholine |
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