Document Detail

The effects of apomorphine on visual perception in patients with Parkinson disease and visual hallucinations: a pilot study.
MedLine Citation:
PMID:  19667979     Owner:  NLM     Status:  In-Process    
Visual hallucinations (VHs) often occur in patients with advanced Parkinson disease (PD). Overstimulation of dopamine receptors has been considered as one of the causes for VHs in PD. However, several clinical studies suggested that apomorphine infusion did not worsen existing VHs in PD, but could even improve VHs in some PD patients. This pilot study included 4 PD patients with VHs, who were examined before, during, and after an intravenous infusion with apomorphine. The examinations included tests for lower- and higher-order visual functions, attention, and motor functions. Apomorphine had a significantly positive effect on contrast sensitivity and showed a significantly negative effect on attention. These results may explain why apomorphine is able to improve VHs in PD in some patients with mainly visual perceptive problems, but may also worsen VHs in other patients because of impaired attention.
Linda Geerligs; Anne Marthe Meppelink; Wiebo H Brouwer; Teus van Laar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical neuropharmacology     Volume:  32     ISSN:  1537-162X     ISO Abbreviation:  Clin Neuropharmacol     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2009-10-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607910     Medline TA:  Clin Neuropharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  266-8     Citation Subset:  IM    
Department of Neurology, University Medical Center Groningen, University of Groningen, Netherlands.
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