Document Detail

The effects of antipsychotics on the density of cannabinoid receptors in the dorsal vagal complex of rats: implications for olanzapine-induced weight gain.
MedLine Citation:
PMID:  18257959     Owner:  NLM     Status:  MEDLINE    
Some atypical antipsychotics clinically used to treat schizophrenia induce weight gain by unknown mechanisms. The dorsal vagal complex (DVC) of the brainstem and the endogenous cannabinoid system are implicated in the regulation of appetite signalling and food intake. We investigated whether antipsychotic drugs alter cannabinoid receptor-binding density in the DVC. Female Spraguewk (short-term) or 120.83, p=0.01). In addition, only chronic olanzapine treatment increased food intake. These results show that olanzapine, an antipsychotic with a high risk of weight gain as a side-effect, significantly decreased cannabinoid receptor binding in the DVC, whilst aripiprazole and haloperidol, antipsychotics with a low risk of weight gain had little or no effect on binding. These results suggest that a mechanism for antipsychotic-induced weight gain may be through the modulation of cannabinoid receptors in the DVC.
Katrina Weston-Green; Xu-Feng Huang; Mei Han; Chao Deng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-07
Journal Detail:
Title:  The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)     Volume:  11     ISSN:  1461-1457     ISO Abbreviation:  Int. J. Neuropsychopharmacol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-01     Completed Date:  2008-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815893     Medline TA:  Int J Neuropsychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  827-35     Citation Subset:  IM    
Centre for Translational Neuroscience, School of Health Sciences, University of Wollongong, Wollongong, NSW, Australia.
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MeSH Terms
Antipsychotic Agents / pharmacology*
Benzodiazepines / pharmacology*
Binding, Competitive / drug effects
Cyclohexanols / pharmacology
Immunosuppressive Agents / pharmacology
Medulla Oblongata / drug effects*
Protein Binding / drug effects
Rats, Sprague-Dawley
Receptors, Cannabinoid / metabolism*
Tritium / metabolism
Weight Gain / drug effects*
Reg. No./Substance:
0/Antipsychotic Agents; 0/Cyclohexanols; 0/Immunosuppressive Agents; 0/Receptors, Cannabinoid; 10028-17-8/Tritium; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 83003-12-7/3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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