Document Detail

The effects of antipsychotics on the density of cannabinoid receptors in the dorsal vagal complex of rats: implications for olanzapine-induced weight gain.
MedLine Citation:
PMID:  18257959     Owner:  NLM     Status:  MEDLINE    
Some atypical antipsychotics clinically used to treat schizophrenia induce weight gain by unknown mechanisms. The dorsal vagal complex (DVC) of the brainstem and the endogenous cannabinoid system are implicated in the regulation of appetite signalling and food intake. We investigated whether antipsychotic drugs alter cannabinoid receptor-binding density in the DVC. Female Spraguewk (short-term) or 120.83, p=0.01). In addition, only chronic olanzapine treatment increased food intake. These results show that olanzapine, an antipsychotic with a high risk of weight gain as a side-effect, significantly decreased cannabinoid receptor binding in the DVC, whilst aripiprazole and haloperidol, antipsychotics with a low risk of weight gain had little or no effect on binding. These results suggest that a mechanism for antipsychotic-induced weight gain may be through the modulation of cannabinoid receptors in the DVC.
Katrina Weston-Green; Xu-Feng Huang; Mei Han; Chao Deng
Related Documents :
6611699 - Energetic limits on reproduction: maternal food intake.
24990069 - Risk factors for eosinophilic esophagitis.
20832439 - Regular consumption of a cereal breakfast. effects on mood and body image satisfaction ...
7338939 - Early indices of methyl mercury toxicity and their use in treatment evaluation.
16730949 - The effect of glutamine and dihydroxyacetone supplementation on food intake, weight gai...
4014499 - Recovery of lipid mass after removal of adipose tissue in ground squirrels.
17872409 - Mass-dependent and -independent fractionation of hg isotopes by photoreduction in aquat...
10791599 - Sources of nitrate exposure in residents of rural areas in quebec, canada.
21180989 - Assessing food dietary intakes in japanese-brazilians using factor analysis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-07
Journal Detail:
Title:  The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)     Volume:  11     ISSN:  1461-1457     ISO Abbreviation:  Int. J. Neuropsychopharmacol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-01     Completed Date:  2008-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815893     Medline TA:  Int J Neuropsychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  827-35     Citation Subset:  IM    
Centre for Translational Neuroscience, School of Health Sciences, University of Wollongong, Wollongong, NSW, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antipsychotic Agents / pharmacology*
Benzodiazepines / pharmacology*
Binding, Competitive / drug effects
Cyclohexanols / pharmacology
Immunosuppressive Agents / pharmacology
Medulla Oblongata / drug effects*
Protein Binding / drug effects
Rats, Sprague-Dawley
Receptors, Cannabinoid / metabolism*
Tritium / metabolism
Weight Gain / drug effects*
Reg. No./Substance:
0/Antipsychotic Agents; 0/Cyclohexanols; 0/Immunosuppressive Agents; 0/Receptors, Cannabinoid; 10028-17-8/Tritium; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 83003-12-7/3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Positive association between resistance to Bacillus thuringiensis and overwintering survival of cabb...
Next Document:  Early symptoms and signs of cognitive deficits might not always be detectable in persons who develop...