| The effects of antihypertensive therapy on haemostatic parameters. | |
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MedLine Citation:
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PMID: 14529558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is extensive trial-based evidence showing that antihypertensive drugs reduce the risk of vascular events (e.g. stroke and myocardial infarction) as well as target organ damage (e.g. left ventricular hypertrophy and microalbuminuria). However, some of these benefits appear to be, at least partially, independent of the extent of blood pressure (BP) lowering. It is also evident that in certain clinical situations some antihypertensive drugs are more effective than others. In this review we discuss the effects of antihypertensive drugs on the endothelium, platelets, fibrinolysis and coagulation. These properties may account for the observed BP-independent actions. Antihypertensive drugs exert multiple effects on the vascular endothelium. These include effects on nitric oxide (NO) and angiotensin II-mediated actions. Many BP lowering drugs can inhibit platelet activity, although the relevance of this property is unknown, especially if patients are also taking platelet inhibitors (e.g. aspirin). Antihypertensive drugs also influence fibrinolysis and coagulation. These effects may be mediated by a variety of mechanisms, including altering insulin sensitivity. The haemostatic actions of antihypertensive drugs deserve greater recognition and further investigation. |
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Authors:
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E S Ganotakis; J A Papadakis; G E Vrentzos; D P Mikhailidis |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current pharmaceutical design Volume: 9 ISSN: 1381-6128 ISO Abbreviation: Curr. Pharm. Des. Publication Date: 2003 |
Date Detail:
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Created Date: 2003-10-07 Completed Date: 2004-02-10 Revised Date: 2006-02-27 |
Medline Journal Info:
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Nlm Unique ID: 9602487 Medline TA: Curr Pharm Des Country: Netherlands |
Other Details:
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Languages: eng Pagination: 2445-64 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Crete, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use* Blood Platelets / drug effects Endothelium / drug effects, physiopathology Evidence-Based Medicine / methods Fibrinolysis / drug effects Hemostasis / drug effects*, physiology* Humans Hypertension / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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