Document Detail

The effects of antihypertensive therapy on haemostatic parameters.
MedLine Citation:
PMID:  14529558     Owner:  NLM     Status:  MEDLINE    
There is extensive trial-based evidence showing that antihypertensive drugs reduce the risk of vascular events (e.g. stroke and myocardial infarction) as well as target organ damage (e.g. left ventricular hypertrophy and microalbuminuria). However, some of these benefits appear to be, at least partially, independent of the extent of blood pressure (BP) lowering. It is also evident that in certain clinical situations some antihypertensive drugs are more effective than others. In this review we discuss the effects of antihypertensive drugs on the endothelium, platelets, fibrinolysis and coagulation. These properties may account for the observed BP-independent actions. Antihypertensive drugs exert multiple effects on the vascular endothelium. These include effects on nitric oxide (NO) and angiotensin II-mediated actions. Many BP lowering drugs can inhibit platelet activity, although the relevance of this property is unknown, especially if patients are also taking platelet inhibitors (e.g. aspirin). Antihypertensive drugs also influence fibrinolysis and coagulation. These effects may be mediated by a variety of mechanisms, including altering insulin sensitivity. The haemostatic actions of antihypertensive drugs deserve greater recognition and further investigation.
E S Ganotakis; J A Papadakis; G E Vrentzos; D P Mikhailidis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  9     ISSN:  1381-6128     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-07     Completed Date:  2004-02-10     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2445-64     Citation Subset:  IM    
Department of Internal Medicine, University of Crete, Greece.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Platelets / drug effects
Endothelium / drug effects,  physiopathology
Evidence-Based Medicine / methods
Fibrinolysis / drug effects
Hemostasis / drug effects*,  physiology*
Hypertension / drug therapy
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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