Document Detail

The effects of the anticonvulsant valproic acid on cerebral indole amine metabolism.
MedLine Citation:
PMID:  387187     Owner:  NLM     Status:  MEDLINE    
The effects of valproic acid (500 mg/kg, ip, 1 h prior to testing) on indole amine metabolism were studied in rats by measurement of the contents of tryptophan, 5-hydroxytryptophan (5-HTP), 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) in the cerebral hemisphere. Tryptophan and 5-HIAA levels were increased, whereas 5-HTP and 5-HT remained unchanged. Furthermore, valproic acid failed to alter the levels of 5-HTP and DOPA, 5-HT and DA, and 5-HIAA in animals pretreated, respectively, with 3-hydroxybenzyl hydrazine (a decarboxylase inhibitor), pargyline (a monoamine oxidase inhibitor), or probenecid (a compound which blocks 5-HIAA transport out of the brain and cerebrospinal fluid). These results militate against the possibility that valproic acid alters the rate of tryptophan hydroxylation or the synthesis of 5-HT. However they do support the concept that valproic acid increases brain 5-HIAA by inhibition of the transport mechanism which removes 5-HIAA from the brain.
V MacMillan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  57     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1980-01-24     Completed Date:  1980-01-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  843-7     Citation Subset:  IM    
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MeSH Terms
5-Hydroxytryptophan / metabolism
Biogenic Amines / metabolism*
Brain / drug effects,  metabolism*
Dopamine / pharmacology
Hydroxyindoleacetic Acid / metabolism
Indoles / metabolism*
Levodopa / metabolism
Serotonin / metabolism
Tryptophan / metabolism
Valproic Acid / pharmacology*
Reg. No./Substance:
0/Biogenic Amines; 0/Indoles; 0/Levodopa; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 56-69-9/5-Hydroxytryptophan; 73-22-3/Tryptophan; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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