Document Detail

The effects of antenatal corticosteroid treatment on IVH-PVh of premature infants.
MedLine Citation:
PMID:  18318674     Owner:  NLM     Status:  MEDLINE    
Intraventricular-periventricular hemorrhage (IVH-PVH) is the most frequent type of intracranial hemorrhage in premature infants and the major cause of neurodevelopmental disabilities in children too. The objective of this work is to evaluate the effects of prenatal corticosteroid treatment on the incidence of IVH-PVH in premature infants. The study enrolled 163 prematures of 26-34 weeks' gestation. They have been divided into two groups: the experimental group (80/163), who have been treated with corticosteroids prenatally and control group (83/163), who have not received such treatment. There is statistically significant difference in IVH-PVH incidence between the experimental group (18/80) and control group (32/83) (chi2 =5,616, p<0,05). There is no statistically significant difference in Apgar score after 5 minutes between the experimental group and control group of IVH-PVH prematures, t= 0,121. There is no statistically significant difference in mean gestation age between the experimental group (30,74 weeks) and control group (29,97 weeks) of IVH-PVH prematures, t= 1,299. There is no statistically significant difference in mean birth weight between the experimental group (1479,44 grams) and control group (1379,37 grams) of IVH-PVH prematures, t= 0,913. Antenatal corticosteroid treatment of premature infants reduced the incidence of IVH-PVH significantly. There is no statistically significant difference in Apgar score after 5 minutes, mean gestation age and mean birth weight between the experimental and control group of IVH PVH prematures.
Hajrija Maksić; Feriha Hadzagić-Catibusić; Suada Heljić; Jadranka Dizdarević
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Bosnian journal of basic medical sciences / Udruženje basičnih mediciniskih znanosti = Association of Basic Medical Sciences     Volume:  8     ISSN:  1512-8601     ISO Abbreviation:  Bosn J Basic Med Sci     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-05     Completed Date:  2008-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101200947     Medline TA:  Bosn J Basic Med Sci     Country:  Bosnia and Hercegovina    
Other Details:
Languages:  eng     Pagination:  58-62     Citation Subset:  IM    
Pediatric Clinic, University of Sarajevo Clinics Centre, Bolnicka 25, 71000 Sarajevo, Bosnia and Herzegovina.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use*
Apgar Score
Birth Weight / physiology
Dexamethasone / therapeutic use*
Gestational Age
Infant, Newborn
Infant, Premature*
Intracranial Hemorrhages / prevention & control*
Pregnancy Trimester, Third*
Prenatal Care
Treatment Outcome
Reg. No./Substance:
0/Adrenal Cortex Hormones; 50-02-2/Dexamethasone

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