| The effects of anesthetic drugs and disease on the chemical regulation of ventilation. | |
| | |
MedLine Citation:
|
PMID: 15949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The anesthesiologist uses a wide spectrum of drugs, including inhalational general anesthetics, barbiturates, benzodiazepines, narcotics analgesics and their antagonists, and neuromuscular blocking drugs. All of these drugs in sufficient dose impair the ventilatory response to chemical stimuli, and may cause inadequate gas exchange. The effect of depression of ventilatory control depends on the magnitude of depression and the coexistence of functional abnormalities in the respiratory system. The functional abnormalities are the result of preexistent pulmonary disease or other disease processes that impair respiratory function, the anticipated effects of major surgery (e.g., pulmonary resection), and the complications of anesthesia and surgery. From a functional viewpoint, the mechanisms of the effects of these disease processes on ventilatory control are: (1) interference with the neurophysiological control of automatic ventilation; (2) impairment of peripheral or central chemoreceptor function; (3) impairment of respiratory muscle function; (4) increase in the mechanical load to breathing as a result of increased resistance or decreased compliance of the respiratory system; and (5) increase in the ventilatory requirements as a result of ventilation/blood flow maldistribution, metabolic acidosis, or increased metabolic rate. As a result of current trends in the use of multiple drugs and controlled ventilation during anesthesia, the patient is at greatest risk during the early postoperative period in the recovery room. In addition to the functional abnormalities described above, the probability of impaired gas exchange and respiratory failure is increased as a result of impaired metabolism and elimination of drugs as a result of hepatic and renal insufficiency, and acute changes in acidbase status, which alter the ionization and distribution of drugs. |
| | |
Authors:
|
E R Kafer; H M Marsh |
Related Documents
:
|
3539269 - Disposition of anesthetic and anesthetic-related agents in ruminants. 6516749 - A specific antihistaminic premedication anti h1 anti h2 for pediatric anesthesia. 14567229 - Evaluation of three combinations of anesthetics for use in free-ranging alpine marmots ... 2656729 - Local anaesthesia of the skin. 4651769 - Anaesthetic, cardiovascular and respiratory effects of a new steroidal agent ct 1341: a... 16454199 - A convenient tlc method for the identification of local anesthetics. 17416569 - In vitro interactions of captopril with h2-receptor antagonists. 15544869 - In vivo release from a drug delivery mems device. 18300579 - Colchicine for the prevention of recurrent pericarditis. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: International anesthesiology clinics Volume: 15 ISSN: 0020-5907 ISO Abbreviation: Int Anesthesiol Clin Publication Date: 1977 |
Date Detail:
|
Created Date: 1977-06-22 Completed Date: 1977-06-22 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0370760 Medline TA: Int Anesthesiol Clin Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1-38 Citation Subset: IM; S |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthetics
/
pharmacology* Anoxia / physiopathology Anti-Anxiety Agents / pharmacology Autonomic Nervous System / physiology Barbiturates / pharmacology Benzodiazepines Carbon Dioxide / pharmacology Fentanyl / pharmacology Halothane / pharmacology Humans Hyperthyroidism / physiopathology Lung Diseases, Obstructive / physiopathology Meperidine / pharmacology Methoxyflurane / pharmacology Morphine / pharmacology Naloxone / pharmacology Neuromuscular Blocking Agents / pharmacology Neuromuscular Diseases / physiopathology Obesity / physiopathology Pulmonary Edema / physiopathology Pulmonary Fibrosis / physiopathology Respiration* / drug effects Scoliosis / physiopathology |
| Chemical | |
Reg. No./Substance:
|
0/Anesthetics; 0/Anti-Anxiety Agents; 0/Barbiturates; 0/Neuromuscular Blocking Agents; 124-38-9/Carbon Dioxide; 12794-10-4/Benzodiazepines; 151-67-7/Halothane; 437-38-7/Fentanyl; 465-65-6/Naloxone; 57-27-2/Morphine; 57-42-1/Meperidine; 76-38-0/Methoxyflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nutrition and enterotoxin synthesis by enterotoxigenic strains of Escherichia coli: defined medium f...
Next Document: Biochemical and physiological approaches to opiate dependence.