Document Detail

The effects of amrinone and glucagon on verapamil-induced myocardial depression in a rat isolated heart model.
MedLine Citation:
PMID:  9184818     Owner:  NLM     Status:  MEDLINE    
1. We measured the ability of glucagon and amrinone, used alone and in combination, to improve the myocardial function in a rat isolated heart model of calcium channel blocker (CCB) cardiotoxicity. 2. Verapamil 10(-4) mol consistently decreased heart rate and cardiac contractile force in our Langendorff rat isolated heart preparations. Glucagon increased the heart rate in a dose-dependent fashion. Amrinone increased the heart rate only at the 1 x 10(-1) mol concentration, and had no significant effect on cardiac contractility. 3. A positive linear correlation was found between the glucagon concentration and the percent recovery of baseline contractile force. 4. Although complete reversal of verapamil-induced myocardial depression occurred at glucagon concentrations of > 3 x 10(-6) mol, amrinone produced only 23.8 +/- 3.6% recovery from baseline at its highest concentration (4 x 10(-3) mol). 5. When glucagon and amrinone were administered together, there was no additional increase over glucagon alone in the increase in contractile force. 6. Glucagon, and not amrinone, is an appropriate agent, capable of reversing verapamil-induced myocardial toxicity in this rat isolated heart model. In vivo studies should be performed to assess whether this may be a reliable therapy in clinical cases.
Y Tuncok; S Apaydin; S Gidener; H Guven; O Oto; M Ates; A Gure
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  General pharmacology     Volume:  28     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-08-15     Completed Date:  1997-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  773-6     Citation Subset:  IM    
Department of Pharmacology, Dokuz Eylul University, Balcova, Izmir, Turkey.
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MeSH Terms
Amrinone / pharmacology*
Calcium Channel Blockers / toxicity*
Depression, Chemical
Glucagon / pharmacology*
Heart / drug effects*
Heart Rate / drug effects
Myocardial Contraction / drug effects
Phosphodiesterase Inhibitors / pharmacology*
Rats, Wistar
Verapamil / toxicity*
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Phosphodiesterase Inhibitors; 52-53-9/Verapamil; 60719-84-8/Amrinone; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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