Document Detail

The effects of amoxicillin therapy on skin flora in infants.
MedLine Citation:
PMID:  11085662     Owner:  NLM     Status:  MEDLINE    
In order to determine the effect of amoxicillin therapy on the perineal skin microbial flora in infants, we took quantitative bacterial and fungal cultures of perineal and sternal areas from 25 infants treated with amoxicillin (40 mg/kg/day) for 10 days. Specimens were obtained prior to therapy, within 3 days of conclusion of therapy, and 14-16 days later. Immediately following therapy, a decline in the number of bacterial isolates occurred on both the perineum (89 to 47) and sternum (84 to 39). The greatest decline occurred in the number of anaerobic bacteria (mostly Peptostreptococcus spp. and Propionibacterium acnes). Other organisms that were less often isolated were aerobic streptococci and Staphylococcus epidermidis. The number of Candida albicans isolates increased from 3 to 11 (p < 0.05) on the perineum, and 1 to 7 (p < 0.025) on the sternum. Four of the infants developed diaper dermatitis. The density of C. albicans increased more than 14-fold following amoxicillin therapy. Cultures done 14-16 days after cessation of therapy revealed an increase in the number of bacterial isolates on the perineum (47 to 72) and on the sternum (39 to 61) and a decline in recovery of C. albicans. This study demonstrates the effects of amoxicillin on the ecology of skin microbial flora in infants-a decrease in the number of bacterial isolates and an increase in recovery of C. albicans.
I Brook
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric dermatology     Volume:  17     ISSN:  0736-8046     ISO Abbreviation:  Pediatr Dermatol     Publication Date:    2000 Sep-Oct
Date Detail:
Created Date:  2001-02-14     Completed Date:  2001-02-15     Revised Date:  2009-03-03    
Medline Journal Info:
Nlm Unique ID:  8406799     Medline TA:  Pediatr Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  360-3     Citation Subset:  IM    
Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA.
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MeSH Terms
Amoxicillin / adverse effects*,  therapeutic use
Bacteria, Aerobic / isolation & purification*
Bacteria, Anaerobic / isolation & purification*
Candida albicans / isolation & purification*
Otitis Media / drug therapy
Penicillins / adverse effects*,  therapeutic use
Perineum / microbiology
Prospective Studies
Skin / microbiology*
Specimen Handling
Sternum / microbiology
Reg. No./Substance:
0/Penicillins; 26787-78-0/Amoxicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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