Document Detail


The effects of amitrole on thyroglobulin and iodide uptake in FRTL-5 cells.
MedLine Citation:
PMID:  20937625     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Thyroid is a frequent target for endocrine effects of pesticides. Thyroglobulin (TG) and iodide uptake are crucial to thyroid hormone synthesis and may be targets of thyroid-disrupting chemicals. In our study, thyroid follicular FRTL-5 cells were treated with amitrole, an inhibitor of the thyroid peroxidase (TPO), and the effects on TG and total iodide uptake were observed. The results showed that 1 -100 mg/L amitrole had no marked effects on FRTL-5 cell proliferation and DNA synthesis. However, it significantly increased the transcription of tg gene and inhibited the total iodide uptake. And 10-100 mg/L amitrole significantly decreased TG in the culture medium. The data suggests amitrole may disrupt the expression and secretion of TG and iodide uptake.
Authors:
Pan Hongmei; Sun Yulan; Zhang Lishi
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Publication Detail:
Type:  Journal Article     Date:  2010-10-11
Journal Detail:
Title:  Toxicology and industrial health     Volume:  27     ISSN:  1477-0393     ISO Abbreviation:  Toxicol Ind Health     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8602702     Medline TA:  Toxicol Ind Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  187-92     Citation Subset:  IM    
Affiliation:
Institute for Health Sciences, Kunming Medical College, Kunming, China.
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