| The effects of amitrole on thyroglobulin and iodide uptake in FRTL-5 cells. | |
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MedLine Citation:
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PMID: 20937625 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Thyroid is a frequent target for endocrine effects of pesticides. Thyroglobulin (TG) and iodide uptake are crucial to thyroid hormone synthesis and may be targets of thyroid-disrupting chemicals. In our study, thyroid follicular FRTL-5 cells were treated with amitrole, an inhibitor of the thyroid peroxidase (TPO), and the effects on TG and total iodide uptake were observed. The results showed that 1 -100 mg/L amitrole had no marked effects on FRTL-5 cell proliferation and DNA synthesis. However, it significantly increased the transcription of tg gene and inhibited the total iodide uptake. And 10-100 mg/L amitrole significantly decreased TG in the culture medium. The data suggests amitrole may disrupt the expression and secretion of TG and iodide uptake. |
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Authors:
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Pan Hongmei; Sun Yulan; Zhang Lishi |
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Publication Detail:
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Type: Journal Article Date: 2010-10-11 |
Journal Detail:
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Title: Toxicology and industrial health Volume: 27 ISSN: 1477-0393 ISO Abbreviation: Toxicol Ind Health Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8602702 Medline TA: Toxicol Ind Health Country: England |
Other Details:
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Languages: eng Pagination: 187-92 Citation Subset: IM |
Affiliation:
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Institute for Health Sciences, Kunming Medical College, Kunming, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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