Document Detail

The effects of aluminum ingestion on intestinal cadmium absorption, lipid peroxidation and alkaline phosphatase activity.
MedLine Citation:
PMID:  1641869     Owner:  NLM     Status:  MEDLINE    
Consumption of dietary aluminum (A1, 2000 or 4000 ppm) for 1 month did not influence mouse body weight. In order to estimate an absorption of cadmium (Cd) from the gastrointestinal tract, mice were intubated twice every 24 h with Cd (CdCl2). In the A1-supplemented mice, Cd absorption increased rather than decreased. Intestinal Cd and metallothionein concentrations were increased by the A1 supplement. Intestinal alkaline phosphatase activity and lipoperoxide concentrations were also enhanced by A1 ingestion. Of course, intestinal A1 concentration was at a high level in the A1-supplemented groups. However, A1 accumulation was not observed in the liver. The increase of Cd absorption may be due to an abnormality of the gut wall caused by the A1. Our results suggest that A1 is not inert for animals, even though A1 absorption is poor.
N Sugawara; C Sugawara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology letters     Volume:  61     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-28     Completed Date:  1992-08-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  225-32     Citation Subset:  IM    
Department of Public Health, Sapporo Medical College, Japan.
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MeSH Terms
Administration, Oral
Alkaline Phosphatase / metabolism*
Aluminum / blood,  toxicity*
Body Weight / drug effects
Cadmium / blood,  pharmacokinetics*
Intestinal Absorption / drug effects
Intestines / drug effects,  enzymology
Lipid Peroxidation / drug effects*
Mice, Inbred ICR
Tissue Distribution
Zinc / blood
Reg. No./Substance:
7429-90-5/Aluminum; 7440-43-9/Cadmium; 7440-66-6/Zinc; EC Phosphatase

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