Document Detail


The effects of altered exercise distribution on lymphocyte subpopulations.
MedLine Citation:
PMID:  8789587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of exercise distribution on lymphocyte count, lymphocyte subpopulations and plasma cortisol concentration in peripheral blood were assessed in 19 healthy subjects. The subjects were randomly divided into group A (n = 10) or group B (n = 9) according to exercise distribution. Both groups underwent a 10-week programme involving 5 x 2-week blocks: baseline (B), training period 1 (TP1), stabilisation 1 (S1), training period 2 (TP2), and stabilisation 2 (S2). During B, S1 and S2 normal training was undertaken. During TP1 and TP2 the subjects increased the amount of training by 50% in week 1 and by 100% in week 2. During TP1 subjects in group A exercised 6 days.week-1, while during TP2 these subjects exercised on 3 alternate days.week-1, but doubled the duration of each training session. The subjects in group B reversed this training order. Blood was collected 36-42 h following exercise period B, and at the end of periods TP1, S1, TP2 and S2, and also 12-18 h following completion of exercise at the end of TP1 and TP2. There were no significant differences (P > 0.05) between the 6 day.week-1 programme and the 3 alternate day.week-1 programme in total lymphocyte count, CD3+, CD4+, CD8+, CD16+, or CD19+ cells, the CD4:CD8 ratio, HLA-DR+ (activated) T cells or plasma cortisol concentrations. Following both TP1 and TP2 there was a nonsignificant decrease in lymphocyte subpopulations. However following both S1 and S2 (baseline training) there was a significant increase in total lymphocyte count, CD3+, CD4+ and CD8+ lymphocytes. The S2 variables statistically significant from B were: total lymphocyte count (P < 0.01), CD3+ T-cells and percentage of circulating lymphocytes (P < 0.01), CD4+ cells (P < or = 0.0001), CD8+ cells (P < 0.05), and HLA-DR+ (activated) T-cells (P < 0.05). The results indicated that provided the amount of exercise is constant for a given period, then exercise distribution is not a critical variable in the alteration of lymphocyte subpopulations that may occur in response to overload training. However 2 weeks of overload training followed by 2 weeks of active recovery (baseline) training may induce an increase in the lymphocyte count.
Authors:
C R Host; K I Norton; T S Olds; E L Lowe; S P Mulligan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  72     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1995  
Date Detail:
Created Date:  1996-10-18     Completed Date:  1996-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  157-64     Citation Subset:  IM; X    
Affiliation:
Faculty of Nursing, University of Sydney, Camperdown N.S.W., Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD19 / analysis
Antigens, CD3 / analysis
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Exercise / physiology*
Female
Humans
Hydrocortisone / blood
Immunophenotyping
Killer Cells, Natural
Lymphocyte Count
Lymphocyte Subsets*
Male
Chemical
Reg. No./Substance:
0/Antigens, CD19; 0/Antigens, CD3; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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