Document Detail


The effects of alpha-trinositol on haemodynamic variables and neuropeptide Y levels in a pilot study of hypertensives and healthy volunteers.
MedLine Citation:
PMID:  7994449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: The aim of this study was to examine the effects of D-myo-inositol-1,2,6-trisphosphate (alpha-trinositol) on haemodynamic variables and neuropeptide Y (NPY) levels in hypertensives and healthy volunteers. METHODS: Hypertensives (n = 13) and normotensives (n = 11) were recruited after a screening of cardiovascular risk factors of all men aged 40 living in a well defined area. The hypertensives were previously unmedicated. The effect of alpha-trinositol was studied after intravenous infusion at rest, and during and after a maximal exercise test in a double-blind crossover manner with placebo. RESULTS: Haemodynamic variables and NPY levels were recorded. NPY levels did not differ between normotensives and mild hypertensives at the start of the study. However, a significant increase was seen in hypertensives after they had risen to the sitting position. During exercise, the NPY levels increased significantly both in normotensives and hypertensives. After the exercise test, the NPY levels were significantly higher in hypertensives than in normotensives; alpha-trinositol did not modify these responses. In normotensives no significant difference in systolic blood pressure was seen during or after the exercise test whether they were on alpha-trinositol or placebo. In the hypertensives on active drug, however, the blood pressure tended to be approximately 5 mmHg lower during the exercise test as compared with the placebo group. In the hypertensives on active drug, the heart rate increased significantly more during exercise as compared with the placebo groups. In normotensives, the same tendency was seen, but it did not reach statistical significance. CONCLUSIONS: The NPY antagonist, alpha-trinositol, tends to reduce the increase in systolic blood pressure induced by maximal exercise and increases the heart rate in hypertensives but not in normotensives.
Authors:
H Lind; L Brudin; J Castenfors; T Hedner; L Lindholm; L Edvinsson
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood pressure     Volume:  3     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1995-01-13     Completed Date:  1995-01-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  242-7     Citation Subset:  IM    
Affiliation:
Mrbylånga Health Centre, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects
Cross-Over Studies
Double-Blind Method
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Hypertension / blood,  physiopathology*
Inositol Phosphates / blood,  pharmacology*
Male
Neuropeptide Y / blood*
Pilot Projects
Chemical
Reg. No./Substance:
0/Inositol Phosphates; 0/Neuropeptide Y; 28841-62-5/inositol 1,2,6-triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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