Document Detail


The effects of alpha lipoic acid on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit.
MedLine Citation:
PMID:  22194111     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The aim of this study is to determine the effects of a strong dithiol antioxidant, alpha lipoic acid (ALA) on cerebral vasospasm following subarachnoid hemorrhage in a rabbit model.
MATERIAL AND METHODS: Twenty-one New Zealand white rabbits were assigned to one of three groups: group 1 (control), group 2 (SAH only), group 3 (SAH+ALA). ALA was administered (100 mg/kg/day, single dose, intraperitoneally). The rabbits were sacrificed 72 hours after SAH. The basilar artery lumen areas, arterial wall thickness and endothelial apoptosis in a cross section of basilar artery were measured in all groups. The tissue MDA, SOD, GSH-Px levels were also determined.
RESULTS: The elevated tissue MDA levels after SAH were significantly reduced by ALA treatment. The reduced tissue SOD and GSH-Px levels after SAH were also elevated by ALA treatment. In the treatment group the average wall thickness and the mean percentages of apoptotic cells (apoptotic index) were reduced and the average cross-sectional areas of the basilar artery were increased statistically significantly.
CONCLUSION: ALA treatment attenuates the severity of cerebral vasospasm by its strong antioxidant, antivasospastic and antiapoptotic properties. ALA may potentially serve as agents in the prevention of cerebral vasospasm after SAH.
Authors:
Mehmet Fatih Erdi; Onder Guney; Aysel Kiyici; Hasan Esen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Turkish neurosurgery     Volume:  21     ISSN:  1019-5149     ISO Abbreviation:  Turk Neurosurg     Publication Date:  2011  
Date Detail:
Created Date:  2011-12-23     Completed Date:  2012-04-24     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9423821     Medline TA:  Turk Neurosurg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  527-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology*,  therapeutic use
Apoptosis / drug effects,  physiology
Basilar Artery / drug effects,  metabolism,  physiopathology
Cerebrovascular Circulation / drug effects,  physiology
Disease Models, Animal
Endothelial Cells / drug effects*,  metabolism
Free Radicals / antagonists & inhibitors,  metabolism
Glutathione Peroxidase / antagonists & inhibitors,  metabolism
Hydrogen Peroxide / metabolism
Male
Malondialdehyde / antagonists & inhibitors,  metabolism
Muscle, Smooth, Vascular / drug effects,  metabolism,  physiopathology
Oxidative Stress / drug effects,  physiology
Rabbits
Subarachnoid Hemorrhage / complications,  physiopathology*
Superoxide Dismutase / antagonists & inhibitors,  metabolism
Thioctic Acid / pharmacology*,  therapeutic use
Treatment Outcome
Vasodilation / drug effects,  physiology
Vasospasm, Intracranial / drug therapy*,  etiology,  physiopathology*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Free Radicals; 4Y8F71G49Q/Malondialdehyde; 73Y7P0K73Y/Thioctic Acid; BBX060AN9V/Hydrogen Peroxide; EC 1.11.1.-/glutathione peroxidase GPX1; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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