Document Detail

The effects of alpha 2-adrenergic stimulation with mivazerol on myocardial blood flow and function during coronary artery stenosis in anesthetized dogs.
MedLine Citation:
PMID:  8615484     Owner:  NLM     Status:  MEDLINE    
The central sympatholytic effect of alpha 2 agonists may be beneficial during myocardial ischemia, but could be opposed by their peripheral vasoconstrictive effect. We studied the effects of mivazerol during periods of moderate coronary artery stenosis in anesthetized dogs. Mivazerol decreased heart rate (from 125 +/- 6 to 106 +/- 6 bpm) and cardiac output (from 4.4 +/- 0.6 to 1.8 +/- 0.2L/min) under normal conditions, while mean arterial pressure did not change. Mivazerol reduced blood flow in nonischemic myocardium and in the ischemic epicardial layer, but blood flow was preserved in the ischemic midmyocardial and subendocardial layer. Mivazerol had no effect on myocardial oxygen extraction during the stenoses, and regional myocardial oxygen consumption was unchanged. However, mivazerol decreased myocardial oxygen demand from 4.51 +/- 0.51 to 3.17 +/- 0.24 mumol.min-1.g-1, thereby reducing oxygen deficiency of ischemic myocardium to values significantly lower than in the placebo group (from 1.07 +/- 0.32 to 0.47 +/- 0.41 mumol.min-1.g-1). Mivazerol had no effect on myocardial lactate production during the stenoses. We conclude that mivazerol reduced myocardial oxygen demand while blood flow was preserved in the inner layers of ischemic myocardium.
P M Roekaerts; F W Prinzen; H M Willigers; S De Lange
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  82     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-06-05     Completed Date:  1996-06-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  702-11     Citation Subset:  AIM; IM    
Department of Anesthesiology, University Hospital of Maastricht, The Netherlands.
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MeSH Terms
Adrenergic alpha-Agonists / administration & dosage*
Cardiac Output / drug effects
Catecholamines / blood
Coronary Circulation / drug effects*
Coronary Disease / physiopathology*
Imidazoles / administration & dosage*,  blood
Myocardial Contraction / drug effects
Myocardium / metabolism
Oxygen Consumption
Regional Blood Flow / drug effects
Vascular Resistance / drug effects
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Catecholamines; 0/Imidazoles; 125472-02-8/mivazerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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