| The effects of alcohol on rat placenta. | |
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MedLine Citation:
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PMID: 15565633 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, daily food and water consumption and body weights, histopathology of placenta, tenascin (TN), type IV collagen and EGF and its receptor immunolocalization in the placenta of albino rats treated with two doses of alcohol (1 and 5 g kg(-1) day(-1)) were determined. Alcohol was administered in three different periods i.e. the whole 4 weeks before the pregnancy, during the pregnancy, and during the 4 weeks before the pregnancy plus pregnancy itself. The samples of placenta obtained from control and treated rats on days 10, 12, 14, 16, 18, 20 and 21 of gestation were evaluated morphologically and fixed for histology and immunohistochemistry. Some differences in food and water consumption between the groups were determined. The placental weight, especially in the groups receiving 1 and 5 g kg(-1) day(-1) alcohol during the pregnancy, showed increases. The changes in placental histology such as increases in the number and the size of trophoblastic giant cells, cytoplasmic dissolution and nuclear polymorphism, degenerations in spongiotrophoblasts, hyperemia at the basal zone and labyrinth, hyperplasia at the labyrinth and irregular vascularization were seen particularly in the groups receiving alcohol during the pregnancy, and during the 4 weeks before the pregnancy plus pregnancy itself. Increases in the immunolocalization of TN and type IV collagen and decreases in the immunolocalization of EGF and EGFR in the placentas of alcohol-receiving rats were found. In conclusion, ethanol treatment during pregnancy in rats affected placentation and the immunolocalization of TN, type IV collagen, EGF and EGFR in the placentas. |
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Authors:
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Mehmet Turan Akay; Evrim Arzu Koçkaya |
Related Documents
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16257353 - Alcohol consumption and serum hormone levels during pregnancy. 20869193 - Radiation exposure and pregnancy. 1202623 - Transplacental passage of foetal blood cells. |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell biochemistry and function Volume: 23 ISSN: 0263-6484 ISO Abbreviation: Cell Biochem. Funct. Publication Date: 2005 Nov-Dec |
Date Detail:
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Created Date: 2005-10-31 Completed Date: 2005-12-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8305874 Medline TA: Cell Biochem Funct Country: England |
Other Details:
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Languages: eng Pagination: 435-45 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2004 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Biology, Faculty of Science, Hacettepe University, 06532 Beytepe, Ankara, Türkiye. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Collagen Type IV / metabolism Energy Intake Epidermal Growth Factor / metabolism Ethanol / pharmacology* Female Placenta / cytology, drug effects*, metabolism, pathology Pregnancy Pregnancy, Animal* Rats Rats, Wistar Receptor, Epidermal Growth Factor / metabolism Tenascin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Collagen Type IV; 0/Tenascin; 62229-50-9/Epidermal Growth Factor; 64-17-5/Ethanol; EC 2.7.10.1/Receptor, Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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