| The effects of aggressive vs. conservative phototherapy on the brainstem auditory evoked responses of extremely-low-birth-weight infants. | |
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MedLine Citation:
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PMID: 22289854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: This study was a two-center, stratified, parallel-group randomized trial comparing the effects of aggressive vs. conservative phototherapy on brainstem auditory evoked response (BAER) latencies in infants with extremely low birth weight (ELBW, ≤ 1,000 g). RESULTS: BAER latencies of 751-1,000 g birth-weight infants were shorter by 0.37 ms (95% confidence interval (CI) = 0.02, 0.73) for wave V, 0.39 ms (0.08, 0.70) for wave III, and 0.33 ms (0.01, 0.65) for wave I after aggressive phototherapy at one center. Interwave intervals did not differ significantly. Similar nonsignificant trends were recorded for 501-750 g birth-weight infants. At the other participating center, no significant differences were recorded, cautioning against overgeneralizing these results. DISCUSSION: The effects of bilirubin on the auditory pathway in ELBW infants depend on a complex interaction of bilirubin exposure, newborn characteristics, and clinical management. METHODS: Aggressive phototherapy was initiated sooner and continued at lower bilirubin levels than conservative phototherapy. A total of 174 ELBW infants were enrolled in the study; 111 infants were successfully tested at 35 weeks postmenstrual age (PMA); 57 died; and 6 were not successfully tested. |
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Authors:
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Robert E Lasky; Michael W Church; Mark S Orlando; Brenda H Morris; Nehal A Parikh; Jon E Tyson; Georgia E McDavid; William Oh; David K Stevenson; Krisa P Van Meurs; Ronnie Guillet; Dale L Phelps |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Pediatric research Volume: 71 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-31 Completed Date: 2012-05-15 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 77-84 Citation Subset: IM |
Affiliation:
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Center for Clinical Research and Evidence-Based Medicine, University of Texas Medical School at Houston, Houston, Texas, USA. Robert.E.Lasky@uth.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bilirubin
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radiation effects Birth Weight Evoked Potentials, Auditory, Brain Stem / physiology* Female Gestational Age Humans Infant, Extremely Low Birth Weight / physiology* Infant, Newborn Male Phototherapy / methods* Reaction Time / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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KL2 RR24149/RR/NCRR NIH HHS; M01 RR44/RR/NCRR NIH HHS; M01 RR70/RR/NCRR NIH HHS; M01 RR7122/RR/NCRR NIH HHS; M01 RR8084/RR/NCRR NIH HHS; U10 HD027904-14/HD/NICHD NIH HHS; U10 HD21373/HD/NICHD NIH HHS; U10 HD21385/HD/NICHD NIH HHS; U10 HD27853/HD/NICHD NIH HHS; U10 HD27880/HD/NICHD NIH HHS; U10 HD27904/HD/NICHD NIH HHS; U10 HD36790/HD/NICHD NIH HHS; U10 HD40498/HD/NICHD NIH HHS; U10 HD40521/HD/NICHD NIH HHS; UL1 RR24148/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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635-65-4/Bilirubin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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