Document Detail


The effects of aggressive vs. conservative phototherapy on the brainstem auditory evoked responses of extremely-low-birth-weight infants.
MedLine Citation:
PMID:  22289854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: This study was a two-center, stratified, parallel-group randomized trial comparing the effects of aggressive vs. conservative phototherapy on brainstem auditory evoked response (BAER) latencies in infants with extremely low birth weight (ELBW, ≤ 1,000 g).
RESULTS: BAER latencies of 751-1,000 g birth-weight infants were shorter by 0.37 ms (95% confidence interval (CI) = 0.02, 0.73) for wave V, 0.39 ms (0.08, 0.70) for wave III, and 0.33 ms (0.01, 0.65) for wave I after aggressive phototherapy at one center. Interwave intervals did not differ significantly. Similar nonsignificant trends were recorded for 501-750 g birth-weight infants. At the other participating center, no significant differences were recorded, cautioning against overgeneralizing these results.
DISCUSSION: The effects of bilirubin on the auditory pathway in ELBW infants depend on a complex interaction of bilirubin exposure, newborn characteristics, and clinical management.
METHODS: Aggressive phototherapy was initiated sooner and continued at lower bilirubin levels than conservative phototherapy. A total of 174 ELBW infants were enrolled in the study; 111 infants were successfully tested at 35 weeks postmenstrual age (PMA); 57 died; and 6 were not successfully tested.
Authors:
Robert E Lasky; Michael W Church; Mark S Orlando; Brenda H Morris; Nehal A Parikh; Jon E Tyson; Georgia E McDavid; William Oh; David K Stevenson; Krisa P Van Meurs; Ronnie Guillet; Dale L Phelps
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatric research     Volume:  71     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-31     Completed Date:  2012-05-15     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-84     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bilirubin / radiation effects
Birth Weight
Evoked Potentials, Auditory, Brain Stem / physiology*
Female
Gestational Age
Humans
Infant, Extremely Low Birth Weight / physiology*
Infant, Newborn
Male
Phototherapy / methods*
Reaction Time / physiology*
Grant Support
ID/Acronym/Agency:
KL2 RR24149/RR/NCRR NIH HHS; M01 RR44/RR/NCRR NIH HHS; M01 RR70/RR/NCRR NIH HHS; M01 RR7122/RR/NCRR NIH HHS; M01 RR8084/RR/NCRR NIH HHS; U10 HD027904/HD/NICHD NIH HHS; U10 HD027904-14/HD/NICHD NIH HHS; U10 HD21373/HD/NICHD NIH HHS; U10 HD21385/HD/NICHD NIH HHS; U10 HD27853/HD/NICHD NIH HHS; U10 HD27880/HD/NICHD NIH HHS; U10 HD27904/HD/NICHD NIH HHS; U10 HD36790/HD/NICHD NIH HHS; U10 HD40498/HD/NICHD NIH HHS; U10 HD40521/HD/NICHD NIH HHS; UL1 RR24148/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
RFM9X3LJ49/Bilirubin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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