Document Detail

The effects of age and various fat/carbohydrate caloric ratios on nitrogen retention and wound healing in rats.
MedLine Citation:
PMID:  2056395     Owner:  NLM     Status:  MEDLINE    
Recent reports have indicated a possible age-related component to the ability of various species to utilize either fat or carbohydrate as their preferential energy source. These studies have demonstrated that infant rats given a high-fat diet (50% fat, 35% carbohydrate, 15% protein) retain a significantly higher amount of nitrogen than do infant rats on a high-carbohydrate diet (82% carbohydrate, 3% fat, 15% protein). Conversely, adult rats maintain a higher positive nitrogen balance when given the high-carbohydrate diet. In light of these studies, and our interest in factors that contribute to wound healing in the surgical patient, we investigated the effects of low-, medium-, and high-fat enteral diets on wound healing and nitrogen balance in surgically stressed rats of various ages. Weanling (45 g) and young adult (175 g) male Sprague-Dawley rats (n = 16 per age group) were housed individually in metabolic cages. All animals had Impra vascular-graft wound cylinders placed subcutaneously in the dorsal midline and were placed in four dietary groups: high fat (50% kcal), medium fat (30% kcal), low fat (2.5% kcal), and chow (Purina Standard Laboratory Rodent Chow, 17% kcal as fat). All test diets were isonitrogenous (3.1 g nitrogen/1,000 kcal) and isocaloric for each age group. Animals in each age group were pair-fed (35 kcal/d, weanlings; 60 kcal/d, young adults) for 10 days and then euthanized. Wound cylinders were removed and analyzed for collagen content.(ABSTRACT TRUNCATED AT 250 WORDS)
P J Hennessey; J G Nirgiotis; R J Andrassy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  26     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-07-31     Completed Date:  1991-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  367-72; discussion 372-3     Citation Subset:  IM    
Department of Surgery, University of Texas Medical School, Houston.
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MeSH Terms
Analysis of Variance
Blood Proteins / analysis
Collagen / analysis
Dietary Carbohydrates / metabolism*
Dietary Fats / metabolism*
Nitrogen / metabolism*
Rats, Inbred Strains
Serum Albumin / analysis
Wound Healing / physiology*
Reg. No./Substance:
0/Blood Proteins; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Serum Albumin; 7727-37-9/Nitrogen; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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