Document Detail


The effects of adrenalectomy and corticosterone replacement on induction of maternal behavior in the virgin female rat.
MedLine Citation:
PMID:  16297919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal behavior of the sensitized virgin rat is affected by approach-avoidance systems as well as by hypothalamic-pituitary-adrenal (HPA) axis, which is also activated during stress. The present experiments investigated the effects of adrenalectomy and of varying corticosterone concentrations on the onset and expression of maternal behavior in sensitized virgin rats. In the first experiment, latency to onset of maternal behavior and time spent licking once maternal were positively related to endogenous levels of corticosterone. However, few rats showed licking. In the second experiment, virgin rats were adrenalectomized or given sham surgeries before being sensitized and being given 0, 25, 100, 300, or 500 microg/mL of corticosterone in their drinking water. In the third experiment, virgin rats were adrenalectomized or given sham surgeries and given either control or corticosterone time-release pellets after being sensitized. Maternal behavior was then tested. Adrenalectomy increased licking in the second experiment and time over pups in the third experiment. Corticosterone replacement reduced licking in the second experiment and both licking and time over pups in the third experiment. In conclusion, exogenous corticosterone had an inhibitory effect on the expression of maternal behavior in the sensitized virgin rat, unlike the facilitatory effect previously found in the postpartum rat.
Authors:
Stephanie L Rees; Sonia Panesar; Meir Steiner; Alison S Fleming
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-17
Journal Detail:
Title:  Hormones and behavior     Volume:  49     ISSN:  0018-506X     ISO Abbreviation:  Horm Behav     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-20     Completed Date:  2006-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337-45     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Toronto at Mississauga, ON, Canada.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adrenalectomy
Analysis of Variance
Animals
Behavior, Animal / physiology*
Corticosterone / administration & dosage,  physiology*
Dose-Response Relationship, Drug
Female
Hypothalamo-Hypophyseal System / physiology
Maternal Behavior / physiology*
Pituitary-Adrenal System / physiology
Rats
Rats, Sprague-Dawley
Reaction Time / physiology*
Chemical
Reg. No./Substance:
50-22-6/Corticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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