Document Detail

The effects of acute treatment with paroxetine, amitriptyline, and placebo on driving performance and cognitive function in healthy Japanese subjects: a double-blind crossover trial.
MedLine Citation:
PMID:  18383000     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effects of antidepressants on driving performance from a different methodological viewpoint in light of the recent traffic accidents. METHODS: In this double-blinded, 3-way crossover trial, 17 healthy males received acute doses of 10 mg paroxetine, 25 mg amitriptyline, and placebo. The subjects were administered three driving tasks--road tracking, car following, and harsh braking--performed using a driving simulator and three cognitive tasks--Wisconsin Card Sorting Test, Continuous Performance Test, and N-back test at baseline and at 1 h and 4 h post-dosing. The Stanford Sleepiness Scale scores were also assessed. RESULTS: At 4 h post-dosing, amitriptyline significantly impaired road-tracking and car-following performance, reduced driver vigilance, and caused subjective somnolence. Paroxetine impaired neither driving performance nor cognitive function. CONCLUSIONS: Acute doses of amitriptyline significantly impaired driving performance in the context of driving on crowded urban roads at relatively low speeds. This setting is important with respect to skills necessary for daily driving and may be difficult to measure in actual driving tests. This simulator-based study replicated the results of previous studies and could be considered complementary to them. This method may enable easy and safe screening of the driving hazard potential of drugs.
Kunihiro Iwamoto; Masahiro Takahashi; Yukako Nakamura; Yukiko Kawamura; Ryoko Ishihara; Yuji Uchiyama; Kazutoshi Ebe; Akiko Noda; Yukihiro Noda; Keizo Yoshida; Tetsuya Iidaka; Norio Ozaki
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human psychopharmacology     Volume:  23     ISSN:  1099-1077     ISO Abbreviation:  Hum Psychopharmacol     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-25     Completed Date:  2008-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702539     Medline TA:  Hum Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  399-407     Citation Subset:  IM    
Copyright Information:
Copyright 2008 John Wiley & Sons, Ltd.
Department of Psychiatry, Graduate School of Medicine, Nagoya University, Japan.
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MeSH Terms
Amitriptyline / adverse effects*
Antidepressive Agents, Second-Generation / adverse effects*
Antidepressive Agents, Tricyclic / adverse effects*
Asian Continental Ancestry Group
Automobile Driving*
Cognition / drug effects
Cross-Over Studies
Double-Blind Method
Paroxetine / adverse effects*
Psychomotor Performance / drug effects
Reaction Time / drug effects
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Antidepressive Agents, Tricyclic; 50-48-6/Amitriptyline; 61869-08-7/Paroxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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