Document Detail


The effects of acute phase proteins on serum albumin, transferrin and haemoglobin in haemodialysis patients.
MedLine Citation:
PMID:  12296612     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, the effects of C-reactive protein (CRP) and ferritin on serum albumin, transferrin and haemoglobin (Hb) were assessed to investigate the relationship between inflammation, hypoalbuminaemia and anaemia in haemodialysis patients. A total of 117 patients who were followed at three haemodialysis units in Kocaeli were enrolled. The mean age was 47.83 +/- 16.85 years. The median time on dialysis was 26 (minimum 1, maximum 209) months. Serum CRP albumin and ferritin concentrations were measured in our laboratory and transferrin, urea reduction ratio (URR) and Kt/V were calculated. There was significant inverse correlation between serum CRP level and albumin (p<0.001), serum CRP and Hb (p<0.001), and serum transferrin and ferritin (p<0.05). There was significant positive correlation between serum albumin and Hb (p<0.001), serum CRP and ferritin (p<0.05), and transferrin and URR (p<0.05). Our findings suggest that inflammation is a contributor in the development of hypoalbuminaemia and anaemia in haemodialysis patients as well as malnutrition and inadequate dialysis.
Authors:
B Kalender; B Mutlu; M Ersöz; A Kalkan; A Yilmaz
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical practice     Volume:  56     ISSN:  1368-5031     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-25     Completed Date:  2002-11-22     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  505-8     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Faculty of Medicine, University of Kocaeli, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Anemia / blood,  diagnosis,  etiology*
C-Reactive Protein / administration & dosage*
Female
Ferritins / administration & dosage*
Hemoglobins / metabolism
Humans
Male
Middle Aged
Nutritional Status
Prospective Studies
Renal Dialysis / adverse effects*
Serum Albumin / deficiency*,  drug effects
Transferrin / metabolism
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Serum Albumin; 11096-37-0/Transferrin; 9007-41-4/C-Reactive Protein; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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