| The effects of acute passive smoke exposure on endothelium-dependent brachial artery dilation in healthy individuals. | |
| | |
MedLine Citation:
|
PMID: 17495271 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Passive smoking has both short-term and long-term vascular effects. It is not clear whether impairment of endothelial function reflects the acute effects of passive smoke exposure or the chronic effects. The purpose of this study was to assess the hypothesis that short-term exposure to passive smoke impairs endothelium-dependent vasodilation in healthy nonsmokers. Eighteen healthy young never smokers (12 men, 6 women) 21 to 55 years old (mean +/- SD: 34 +/-9 years) underwent ultrasonography measuring baseline brachial-artery diameter and brachial-artery diameter during hyperemia and after sublingual administration of nitroglycerin, twice: in a smoke-free environment, and then in the same environment polluted by 30 to 35 ppm carbon monoxide. Each subject served as his/her control. Carboxyhemoglobin was measured in blood samples of subjects tested. Mean value of carboxyhemoglobin was 0.6 +/-0.5% in a smoke-free environment and 1.4 +/- 0.5% in a smoking environment (p <0.02). Mean values of flow-mediated dilation (FMD) were 12.6% +/- 7.8% in a smoke-free environment versus 6.8 +/- 7.8% in a smoking environment (p <0.01). On the contrary, nitroglycerin-induced vasodilation did not show any statistical difference (21 +/- 9.8% versus 23 +/-1.4%). Finally, the increase of carboxyhemoglobin was related statistically to the impairment of flow-mediated dilation (r = 0.51; p <0.002). Passive smoking impaired flow-mediated vasodilation in healthy never smokers in a smoking environment. The impairment was strongly related to carboxyhemoglobin level. |
| | |
Authors:
|
D Giannini; A Leone; D Di Bisceglie; M Nuti; G Strata; F Buttitta; L Masserini; A Balbarini |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Angiology Volume: 58 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 2007 Apr-May |
Date Detail:
|
Created Date: 2007-05-14 Completed Date: 2007-06-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
|
Languages: eng Pagination: 211-7 Citation Subset: IM |
Affiliation:
|
Angiology University of Pisa, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Analysis of Variance Brachial Artery* / drug effects, ultrasonography Carboxyhemoglobin / analysis Dilatation, Pathologic / chemically induced Endothelium, Vascular / drug effects* Female Humans Male Middle Aged Tobacco Smoke Pollution / adverse effects* Vasodilation / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Tobacco Smoke Pollution; 9061-29-4/Carboxyhemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Success, safety, and efficacy of implantation of diamond-like carbon-coated stents.
Next Document: QT interval analysis in patients with chronic liver disease: a prospective study.