| The effects of acute norepinephrine-induced hypertension on the coronary arteries of newborn piglets. | |
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MedLine Citation:
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PMID: 8941043 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Newborn piglets were subjected to 45 min of sustained norepinephrine-induced hypertension and then monitored for 4 hr at baseline conditions. They were then sacrificed and the anterior descending coronary artery was serially sectioned for study by light and electron microscopy. Other groups were sacrificed after 72 and 168 hr of baseline conditions. Changes were limited to the endothelium and subendothelial intima of the most proximal segment of the anterior descending coronary artery. As similar changes are normally present in perinatal piglets, the experimental animals were compared with sham-operated controls to determine if there was a modification of the naturally occurring congenital lesions. Although the prevalence of coronary lesions in control and experimental animals was not significantly different, the experimental groups showed unique features. At 4 hr, there was marked intimal edema and disruption of the endothelium with fragmentation and dissolution of the internal elastic lamina. There was selective invasion of the intima by platelets and monocytemacrophages. After 72 and 168 hr, there was an increase and progression in preexisting modified smooth muscle cell plaques in which there developed prominent fibroplasia and collagenization. It is proposed that acute hypertension may be responsible for these changes. Such perinatal surges in blood pressure may be involved in the initiation of atherogenesis. |
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Authors:
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R P Bolande; E A Leistikow; F S Wartmann; T M Louis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental and molecular pathology Volume: 63 ISSN: 0014-4800 ISO Abbreviation: Exp. Mol. Pathol. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1997-01-02 Completed Date: 1997-01-02 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370711 Medline TA: Exp Mol Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 87-100 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Coronary Vessel Anomalies Coronary Vessels / drug effects*, pathology, ultrastructure Endothelium / drug effects, ultrastructure Hypertension / chemically induced*, pathology Microscopy, Electron Norepinephrine / toxicity* Swine Tunica Intima / drug effects, ultrastructure |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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