| The effects of activated complement on myocardial performance in vitro. | |
| | |
MedLine Citation:
|
PMID: 2745518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Activated complement has been implicated in the dysfunction of several organ systems, but can it directly affect the myocardium? This possibility was studied using human right atrial trabeculae contracting isometrically "in vitro" in four solutions: Tyrode's (T), autologous arterial blood (B), plasma (P) and denaturated plasma (DP). Complement was activated by the addition of Zymosan while vehicle alone was used as control. Complement activation occurred in the blood and plasma solutions, as assessed by a significant drop in CH50 (p less than 0.05), while there was no detectable complement activity in either T or DP. Myocardial functional integrity was assessed by the change in contractile parameters with time. Subsequent resting forces, relative developed forces (DF), and rates of decay of DF were similar between muscles contracting in the four solutions. We conclude that activated complement has no direct effect on myocardial performance. |
| | |
Authors:
|
P J Hendry; G C Taichman; G P Biro; L G Filion; W J Keon |
Related Documents
:
|
3945948 - 31p nmr studies of the intact perfused rat heart: a novel analytical approach for deter... 23386948 - Hemorrhagic cardioembolic stroke secondary to a left ventricular thrombus: a therapeuti... 2479208 - Mechanisms of anesthesia-induced depression of myocardial function. 1462898 - Inosine--a natural modulator of contractility and myocardial blood flow in the ischemic... 22392328 - Micrornas as biomarkers for myocardial infarction. 16716818 - The spectrum of pleural effusions after coronary artery bypass grafting surgery. |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: The Journal of cardiovascular surgery Volume: 30 ISSN: 0021-9509 ISO Abbreviation: J Cardiovasc Surg (Torino) Publication Date: 1989 May-Jun |
Date Detail:
|
Created Date: 1989-08-17 Completed Date: 1989-08-17 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0066127 Medline TA: J Cardiovasc Surg (Torino) Country: ITALY |
Other Details:
|
Languages: eng Pagination: 351-8 Citation Subset: IM |
Affiliation:
|
University of Ottawa Heart Institute, Ottawa Civic Hospital, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Complement Activation* Complement System Proteins / physiology* Female Heart Atria Humans Isotonic Solutions Male Middle Aged Myocardial Contraction* Plasma Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Isotonic Solutions; 0/Tyrode's solution; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heparin need of the patients with cyanotic congenital heart disease during cardiopulmonary bypass. C...
Next Document: Complement activation during cardiopulmonary bypass.