Document Detail

The effects of acoustic environment after traumatic noise exposure on hearing and outer hair cells.
MedLine Citation:
PMID:  19450428     Owner:  NLM     Status:  MEDLINE    
Previous studies reported that exposure to non-traumatic level sounds after traumatic noise exposure reduced the degree of noise-induced hearing loss and hair cell stereocilia damage. The current study investigated the effects of a 3-day post-noise acoustic environment on the degree of noise-induced hearing loss and cochlear damage. Female chinchillas were exposed to traumatic continuous noise (4 kHz octave-band noise) at 107 dB SPL for 1h and then placed in either an augmented acoustic environment (AAE) or deprived acoustic environment (DAE) for 3 days. The AAE group was exposed to a broad-band noise (4-20 kHz) at 80 dB SPL and the DAE animals were fit with conventional earplugs to minimize the level of acoustic stimulation. Auditory brainstem responses (ABRs) were recorded before and 3 days after the traumatic noise exposure. The AAE group showed a significantly lower average threshold shift at the frequencies of 4 and 8 kHz (p<0.01). Correspondingly, significantly fewer missing and dying outer hair cells (OHCs) were observed in the AAE group than in the DAE group. Although the cochlear reduced and oxidized glutathione levels (GSH and GSSG, respectively) were essentially the same in two groups at day 3, significant correlations were found between GSSG levels and mean ABR threshold shift (1-16 kHz) in the AAE group; as well as GSSG and percentage of total OHC loss in the DAE group. The results suggest that post-noise acoustic environment influenced the degree of hearing loss and OHC deterioration after traumatic noise exposure.
Chiemi Tanaka; Guang-Di Chen; Bo Hua Hu; Lai-Har Chi; Manna Li; Guiliang Zheng; Eric C Bielefeld; Samson Jamesdaniel; Donald Coling; Donald Henderson
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Publication Detail:
Type:  Journal Article     Date:  2009-02-11
Journal Detail:
Title:  Hearing research     Volume:  250     ISSN:  1878-5891     ISO Abbreviation:  Hear. Res.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-20     Completed Date:  2009-07-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  10-8     Citation Subset:  IM    
Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA.
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MeSH Terms
Acoustic Impedance Tests
Acoustic Stimulation / methods
Auditory Threshold
Cochlea / metabolism
Evoked Potentials, Auditory, Brain Stem
Glutathione / metabolism
Glutathione Disulfide / metabolism
Hair Cells, Auditory, Outer / pathology,  physiology
Hearing Loss, Noise-Induced / etiology,  pathology,  physiopathology,  prevention & control*
Microscopy, Confocal
Reg. No./Substance:
27025-41-8/Glutathione Disulfide; 70-18-8/Glutathione

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