Document Detail


The effects of abdominal irradiation for seminoma of the testis on gastrointestinal function.
MedLine Citation:
PMID:  7787155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the long-term effects of abdominal irradiation for the treatment of seminoma of the testis on gastrointestinal function, 15 randomly selected patients who had been treated for stage I seminoma of the testis 2-10 years previously had the following parameters of gastrointestinal function evaluated: gastrointestinal symptoms; absorption of bile acid; vitamin B12; lactose and fat; gastric emptying; small intestinal and total gut transit; and intestinal permeability. Results were compared to those obtained in 18 normal volunteers. There was an increased prevalence of gastrointestinal symptoms (P < 0.01) in the patients and stool frequency was above the control range in two of them. Gastric emptying was faster (P < 0.01) in the patients. There were no significant differences in vitamin B12, bile acid, lactose or fat absorption, small intestinal transit or whole gut transit between the two groups, although faecal fat excretion was greater than the control range in three of the patients. At least one parameter of gastrointestinal function was abnormal in 11 of the 15 patients. Patients with right-sided seminoma had a greater bowel frequency when compared to those with left-sided seminoma (P < 0.05). We conclude that mild abnormalities in gastrointestinal function occur frequently when abdominal irradiation is used to treat stage I seminoma.
Authors:
E Yeoh; M Horowitz; A Russo; T Muecke; T Robb; B Chatterton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  10     ISSN:  0815-9319     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:    1995 Mar-Apr
Date Detail:
Created Date:  1995-07-25     Completed Date:  1995-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  125-30     Citation Subset:  IM    
Affiliation:
Department of Radiation Oncology, Royal Adelaide Hospital, Australia.
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MeSH Terms
Descriptor/Qualifier:
Abdomen / radiation effects
Adult
Aged
Digestive System / physiopathology,  radiation effects*
Follow-Up Studies
Gastrointestinal Diseases / etiology
Gastrointestinal Transit / radiation effects
Humans
Intestinal Absorption / radiation effects
Male
Middle Aged
Permeability / radiation effects
Radiotherapy / adverse effects
Seminoma / radiotherapy*
Testicular Neoplasms / radiotherapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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