| The effects of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia in dogs. | |
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MedLine Citation:
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PMID: 18466161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the influence of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and reduction in pulse rate (PR) in dogs. STUDY DESIGN: Randomized, cross-over. Animals Six healthy laboratory Beagles. METHODS: All animals received dexmedetomidine (5 microg kg(-1) IV, DEX) alone or in combination with L-659,066 (250 microg kg(-1) IV, DEX + L) with a 7-day rest period between treatments. Sedation was assessed using a composite sedation score and PRs were recorded. Atipamezole (50 microg kg(-1) IM, ATI) was administered to reverse the sedation. Overnight Holter-monitoring was carried out to obtain a minimum heart rate (MHR) at rest. RESULTS: Bioequivalence was shown for clinical sedation between DEX and DEX + L. Heart rate was significantly higher with DEX + L during the period of sedation. Bioequivalence was demonstrated between MHR and PR in the DEX + L group during the period of sedation. Recoveries after ATI were uneventful. CONCLUSIONS: L-659,066 did not affect the quality of dexmedetomidine-induced sedation whilst it attenuated the reduction in PR. Thus, L-659,066 could prove a useful adjunct to reduce the peripheral cardiovascular effects attributed to dexmedetomidine in dogs. CLINICAL RELEVANCE: The clinical safety of alpha2-adrenoceptor agonists could be markedly improved with less peripheral cardiovascular effects. |
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Authors:
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Juhana M Honkavaara; Marja R Raekallio; Erja K Kuusela; Esko A Hyvärinen; Outi M Vainio |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2008-05-05 |
Journal Detail:
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Title: Veterinary anaesthesia and analgesia Volume: 35 ISSN: 1467-2995 ISO Abbreviation: Vet Anaesth Analg Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-16 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100956422 Medline TA: Vet Anaesth Analg Country: England |
Other Details:
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Languages: eng Pagination: 409-13 Citation Subset: IM |
Affiliation:
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Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Finland. jussi.honkavaara@helsinki.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic Antagonists
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pharmacology Anesthesia / adverse effects, veterinary Animals Bradycardia / chemically induced, drug therapy, veterinary* Cross-Over Studies Dexmedetomidine / pharmacology* Dog Diseases / chemically induced* Dogs Hypnotics and Sedatives / pharmacology* Quinolizines / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Antagonists; 0/Hypnotics and Sedatives; 0/Quinolizines; 113775-47-6/Dexmedetomidine; 114914-42-0/L 659066 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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