Document Detail

The effects of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and bradycardia in dogs.
MedLine Citation:
PMID:  18466161     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the influence of L-659,066, a peripheral alpha2-adrenoceptor antagonist, on dexmedetomidine-induced sedation and reduction in pulse rate (PR) in dogs. STUDY DESIGN: Randomized, cross-over. Animals Six healthy laboratory Beagles. METHODS: All animals received dexmedetomidine (5 microg kg(-1) IV, DEX) alone or in combination with L-659,066 (250 microg kg(-1) IV, DEX + L) with a 7-day rest period between treatments. Sedation was assessed using a composite sedation score and PRs were recorded. Atipamezole (50 microg kg(-1) IM, ATI) was administered to reverse the sedation. Overnight Holter-monitoring was carried out to obtain a minimum heart rate (MHR) at rest. RESULTS: Bioequivalence was shown for clinical sedation between DEX and DEX + L. Heart rate was significantly higher with DEX + L during the period of sedation. Bioequivalence was demonstrated between MHR and PR in the DEX + L group during the period of sedation. Recoveries after ATI were uneventful. CONCLUSIONS: L-659,066 did not affect the quality of dexmedetomidine-induced sedation whilst it attenuated the reduction in PR. Thus, L-659,066 could prove a useful adjunct to reduce the peripheral cardiovascular effects attributed to dexmedetomidine in dogs. CLINICAL RELEVANCE: The clinical safety of alpha2-adrenoceptor agonists could be markedly improved with less peripheral cardiovascular effects.
Juhana M Honkavaara; Marja R Raekallio; Erja K Kuusela; Esko A Hyvärinen; Outi M Vainio
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-05-05
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  35     ISSN:  1467-2995     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-16     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  409-13     Citation Subset:  IM    
Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Finland.
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MeSH Terms
Adrenergic Antagonists / pharmacology
Anesthesia / adverse effects,  veterinary
Bradycardia / chemically induced,  drug therapy,  veterinary*
Cross-Over Studies
Dexmedetomidine / pharmacology*
Dog Diseases / chemically induced*
Hypnotics and Sedatives / pharmacology*
Quinolizines / pharmacology*
Reg. No./Substance:
0/Adrenergic Antagonists; 0/Hypnotics and Sedatives; 0/Quinolizines; 113775-47-6/Dexmedetomidine; 114914-42-0/L 659066

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