| The effects of IL-32 on the inflammatory activation of cultured rat primary astrocytes. | |
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MedLine Citation:
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PMID: 20888796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new family of cytokine IL-32 has been implicated in pro-inflammatory immune responses several human diseases such as rheumatoid arthritis, inflammatory bowel diseases and vasculitis. In this study, we investigated the role of IL-32 in the inflammatory activation of cultured rat primary astrocytes. Treatment of IL-32 increased ROS production and augmented lipopolysaccharide-induced increased production of nitric oxide as well as the expression of iNOS. IL-32 also induced the expression of MMP-9 but not MMP-2 in rat primary astrocytes. The increased expression of these inflammatory mediators was accompanied by the increased mRNA expression encoding iNOS, MMP-9 and TNF-α. ERK1/2 and p38, two essential regulators of pro-inflammatory signaling in rat primary astrocytes were activated by IL-32 as evidenced by increased phosphorylation. The results from the present study suggest that IL-32 may play a role in the regulation of neuroinflammatory responses in several neurological disease conditions such as ischemia and Alzheimer's disease. |
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Authors:
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Kyu Suk Cho; Seung Hwa Park; So Hyun Joo; Soo-Hyun Kim; Chan Young Shin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-01 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 402 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-03 Completed Date: 2010-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 48-53 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neuroscience, School of Medicine, and IBST, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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metabolism Animals Astrocytes / drug effects, metabolism* Brain Ischemia / metabolism Cells, Cultured Encephalitis / metabolism* Humans Interleukins / pharmacology, physiology* Lipopolysaccharides / immunology Matrix Metalloproteinase 2 / metabolism Matrix Metalloproteinase 9 / metabolism Mitogen-Activated Protein Kinase 1 / metabolism Mitogen-Activated Protein Kinase 3 / metabolism Nitric Oxide / biosynthesis Nitric Oxide Synthase Type II / metabolism Rats Reactive Oxygen Species / metabolism Recombinant Proteins / pharmacology Tumor Necrosis Factor-alpha / metabolism p38 Mitogen-Activated Protein Kinases / metabolism |
| Chemical | |
Reg. No./Substance:
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0/IL32 protein, human; 0/Interleukins; 0/Lipopolysaccharides; 0/Reactive Oxygen Species; 0/Recombinant Proteins; 0/Tumor Necrosis Factor-alpha; 10102-43-9/Nitric Oxide; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nos2 protein, rat; EC 2.7.11.24/MAPK1 protein, human; EC 2.7.11.24/Mitogen-Activated Protein Kinase 1; EC 2.7.11.24/Mitogen-Activated Protein Kinase 3; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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