| The effects of HIV on P300 are moderated by familial risk for substance dependence: implications for a theory of brain reserve. | |
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MedLine Citation:
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PMID: 18065165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The goal of the study was to test the validity of additive versus synergistic versus underadditive versions of brain reserve theory within the context of HIV/AIDS. In addition, it tested the convergent validity of 2 operational definitions of premorbid reserve: verbal IQ (VIQ) and a family history (FH) of substance abuse or dependence. METHODS: Seventy HIV-1 seronegative and 115 HIV-1 seropositive male and female volunteers were assigned to 4 subgroups defined by the crossing of a VIQ score < versus > or = 90 with the presence versus absence of a paternal history of alcohol, cocaine, or opiate abuse or dependence. The principal dependent measure was the P300 event related brain potential elicited during the Stroop color-word interference task. RESULTS: The principal finding was an underadditive effect of FH plus HIV/AIDS on P300 area over the frontal region: FH reduced frontal scalp P300 to such a degree that the additional effects of HIV/AIDS were blunted. The alternate operational definition of brain reserve, VIQ, had no effect on P300 and did not alter the effects of HIV/AIDS. CONCLUSIONS: Familial risk for substance dependence and low VIQ compromise different aspects of brain structure and/or function and therefore differ in their relationship to HIV/AIDS and P300. Genetic differences associated with familial risk may reduce brain reserve to such a degree that the neurophysiological effects of HIV/AIDS can no longer be measured. |
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Authors:
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Lance O Bauer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-12-11 |
Journal Detail:
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Title: Drug and alcohol dependence Volume: 94 ISSN: 0376-8716 ISO Abbreviation: Drug Alcohol Depend Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-02-22 Completed Date: 2008-06-27 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7513587 Medline TA: Drug Alcohol Depend Country: Ireland |
Other Details:
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Languages: eng Pagination: 92-100 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030-2103, United States. bauer@psychiatry.uchc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD4 / immunology Brain / physiopathology* Electroencephalography Event-Related Potentials, P300 / physiology* Female HIV Infections / epidemiology*, immunology Humans Male Substance-Related Disorders* / epidemiology, genetics, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR006192-120198/RR/NCRR NIH HHS; M01 RR006192-137384/RR/NCRR NIH HHS; M01RR06192/RR/NCRR NIH HHS; P50AA03510/AA/NIAAA NIH HHS; R01 DA017666-03/DA/NIDA NIH HHS; R01 MH061346-05/MH/NIMH NIH HHS; R01MH61346/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD4 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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