Document Detail


The effects of GLP-1 infusion in the hepatic portal region on food intake.
MedLine Citation:
PMID:  19289143     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A wide range of evidence points to a role for GLP-1 to regulate food intake. Anorectic effects of GLP-1 are most apparent when the peptide is administered directly into the central nervous system (CNS), but suppression of food intake has also been noted in some cases with peripheral administration. It is unclear which GLP-1 receptor (GLP-1r) population mediates the effects of plasma GLP-1, although direct actions to activate CNS neurons have been demonstrated. More recently several groups have demonstrated that GLP-1 can activate peripheral nerves in the hepatic portal vein to regulate glucose metabolism. To test the hypothesis that GLP-1 receptors on nerve terminals in the hepatic portal affect feeding behavior, we compared the effects of direct infusions into hepatic portal and jugular veins in rats. Jugular GLP-1 decreased food intake at doses as low as 10 microg from 0.5-4 h into the dark cycle, whereas portal GLP-1 decreased food intake only at the highest dose tested (100 microg). The blockade of endogenous GLP-1 action before or during eating by infusing dH-Ex, GLP-1 receptor antagonist, into either jugular or portal vein did not cause any change in food intake during either the dark or light cycles. Taken together, these data suggest that while peripheral GLP-1 may be involved in the regulation of food intake, the key GLP-1 receptors are unlikely to be those associated with vagal afferent nerves innervating the hepatic portal vein.
Authors:
Dong-Hoon Kim; David A D'Alessio; Stephen C Woods; Randy J Seeley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-03-14
Journal Detail:
Title:  Regulatory peptides     Volume:  155     ISSN:  1873-1686     ISO Abbreviation:  Regul. Pept.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-02     Completed Date:  2009-08-17     Revised Date:  2013-03-19    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  110-4     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Eating / drug effects*
Glucagon-Like Peptide 1 / administration & dosage,  pharmacology*
Incretins / administration & dosage,  pharmacology*
Injections, Intraventricular / methods*
Liver / blood supply*
Male
Portal Vein*
Rats
Rats, Long-Evans
Receptors, Glucagon / antagonists & inhibitors
Grant Support
ID/Acronym/Agency:
DK54890/DK/NIDDK NIH HHS; DK56863/DK/NIDDK NIH HHS; P01 DK056863/DK/NIDDK NIH HHS; P01 DK056863-050003/DK/NIDDK NIH HHS; R01 DK054890/DK/NIDDK NIH HHS; R01 DK054890-11/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Incretins; 0/Receptors, Glucagon; 0/glucagon-like peptide-1 receptor; 89750-14-1/Glucagon-Like Peptide 1
Comments/Corrections

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