Document Detail

The effects of Eucheuma cottonii on alveolar macrophages and malondialdehyde levels in bronchoalveolar lavage fluid in chronically particulate matter 10 coal dust-exposed rats.
MedLine Citation:
PMID:  25429347     Owner:  NLM     Status:  Publisher    
OBJECTIVES: To investigate the effect of Eucheuma cottonii on alveolar macrophages (AM) and malondialdehyde (MDA) levels in bronchoalveolar lavage fluids (BALF) in particulate matter 10 (PM10) coal dust-exposed rats.
MATERIALS AND METHODS: Ten groups, including a non exposed group and groups exposed to coal dust at doses of 6.25 (CD6.25), 12.5 (CD12.5), or 25 mg/m(3) (CD25) an hour daily for 6 months with or without supplementation of ethanolic extract of E. cottonii at doses of 150 (EC150) or 300 mg/kg BW (EC300). The number of macrophages was determined using a light microscope. MDA levels were measured by TBARS assay.
RESULTS: EC150 insignificantly (P > 0.05) reduces the AM in CD groups compared to non treatment groups. EC150 and EC300 significantly (P < 0.05) decreased MDA levels in CD12.5 and CD25 groups relative to non treatment groups.
CONCLUSION: E. cottonii attenuated oxidative stress in chronic exposure of PM10 coal dust.
Romadhiyana Kisno Saputri; Bambang Setiawan; Dian Nugrahenny; Nia Kania; Endang Sri Wahyuni; M Aris Widodo
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Publication Detail:
Journal Detail:
Title:  Iranian journal of basic medical sciences     Volume:  17     ISSN:  2008-3866     ISO Abbreviation:  Iran J Basic Med Sci     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-11-27     Completed Date:  -     Revised Date:  2014-11-28    
Medline Journal Info:
Nlm Unique ID:  101517966     Medline TA:  Iran J Basic Med Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  541-545     Citation Subset:  -    
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