Document Detail


The effects of Depo-Provera on serum protein levels in Nigerian women.
MedLine Citation:
PMID:  6231426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentration of 13 serum proteins were determined in 50 women who had received the 3-monthly intramuscular injection of Depo-Provera for contraception over a mean period of 18 months and 40 women of comparable ages who served as controls. Sera from fasting subjects were used to determine the levels of each specific protein by quantitative immunodiffusion technique. Treatment with Depo-Provera produced increased serum levels of albumin, alpha 1-acid glycoprotein, alpha 2-macroglobulin, haptoglobin IgG; reduced levels of alpha 1-antitrypsin, transferrin, C3c, C4 but no change in serum IgA, IgM, C-reactive protein and ceruloplasmin. The significant alterations were observed in serum proteins that are notably synthesized by the liver, an observation consistent with the influences which gonadal hormones exert on the metabolic activities of this organ.
Authors:
J O Fajumi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of steroid biochemistry     Volume:  20     ISSN:  0022-4731     ISO Abbreviation:  J. Steroid Biochem.     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-05-03     Completed Date:  1984-05-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0260125     Medline TA:  J Steroid Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  581-3     Citation Subset:  IM; J    
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MeSH Terms
Descriptor/Qualifier:
Blood Proteins / metabolism*
Delayed-Action Preparations
Female
Humans
Medroxyprogesterone / analogs & derivatives*,  pharmacology
Medroxyprogesterone Acetate
Nigeria
Serum Albumin / metabolism
Serum Globulins / metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Delayed-Action Preparations; 0/Serum Albumin; 0/Serum Globulins; 520-85-4/Medroxyprogesterone; 71-58-9/Medroxyprogesterone Acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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