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The effects of Cinnarizine Versus Sodium Valproate in Migraine Prophylaxis.
MedLine Citation:
PMID:  23311688     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT Aim: The aim of this randomized, double-blind, parallel-group study was to compare the efficacy and safety of low dose cinnarizine and sodium valproate in migraine prophylaxis. Methods: A total of 104 patients were treated during a 12-week treatment period. 25 mg Cinnarizine and 200 mg sodium valproate were administered every 12 hours. During follow-up period, frequency, intensity and duration of migraine attacks, symptoms associated with headache, analgesics use, as well as drugs' side effects were studied. Participants completed MIDAS and HIT-6 questionnaires before and after treatment. Results: Frequency, intensity, and duration of migraine headaches as well as MIDAS score and administration of symptomatic medications decreased significantly between repeated follow-up visits in both groups. Reduction of 4-week migraine frequencies in patients receiving cinnarizine and valproate was 36.4% and 55%, respectively, and the difference between two groups was statistically significant (p<0.001). Conclusion: 0ur results showed that administration of 25 mg cinnarizine every 12 hours can significantly decrease headache duration (p≤0.001) and headache frequency (p≤0.001) in patients with migraine. These results suggest that Cinnarizine may be an appropriate substitution for first-line migraine prophylaxis such as valproate.
Authors:
Arash Bostani; Aref Rajabi; Nasrin Moradian; Nazanin Razazian; Mansour Rezaei
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-13
Journal Detail:
Title:  The International journal of neuroscience     Volume:  -     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Neurology, Kermanshah University of Medical Sciences , Kermanshah , Islamic Republic of Iran.
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