Document Detail

The effects of Carbogen, carbon dioxide, and oxygen on noise-induced hearing loss.
MedLine Citation:
PMID:  1769919     Owner:  NLM     Status:  MEDLINE    
An investigation into the effect of Carbogen (95% O2/5% CO2), 5% CO2/air, and 100% oxygen on cochlear threshold shifts caused by noise was undertaken. Five groups of eight pigmented guinea pigs were exposed to 105 dB broad band noise for 6 h per day for five consecutive days with each group receiving the various gaseous mixtures either during noise exposure or for 1 h immediately after noise exposure. A control group received the same noise exposure but respired air. Auditory threshold shifts, as measured by the auditory evoked brainstem response, were measured at 2,4,8,12,16, 20 and 24 kHz. Recordings were taken pre-exposure and at Day 1, 3, 5, and Weeks 2 and 3 after noise exposure. Carbogen, given during noise exposure, resulted in a trend toward less post noise exposure threshold shift (as compared to controls) which reached statistical significance by Week 3 at all frequencies except 2 and 20 kHz. Subjects given Carbogen after exposure also showed a general trend toward decreased noise induced threshold shifts, as compared to controls, but this was not statistically significant. The mixture of 5% CO2/air given during noise exposure yielded no difference in threshold shifts as compared to controls. When 100% oxygen was administered during noise exposure, a marked decrease in noise induced threshold shifts could be seen as compared to controls, with differences reaching statistical significance by day 5 at most frequencies. These results indicate that oxygen (i.e. cochlear-oxygenation) is a more important factor than CO2 (i.e., as a vasodilator) in protection of the cochlea from noise induced damage.
M Hatch; M Tsai; M J LaRouere; A L Nuttall; J M Miller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hearing research     Volume:  56     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-02-24     Completed Date:  1992-02-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  265-72     Citation Subset:  IM    
University of Michigan Medical School, Ann Arbor 48109-0506.
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MeSH Terms
Auditory Threshold / drug effects
Carbon Dioxide / pharmacology*
Cochlea / blood supply,  drug effects
Evoked Potentials, Auditory, Brain Stem
Guinea Pigs
Hearing Loss, Noise-Induced / etiology,  prevention & control*
Noise / adverse effects
Oxygen / pharmacology*
Regional Blood Flow / drug effects
Vasodilation / drug effects
Grant Support
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 8063-77-2/carbogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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